Identification of the Fc-alpha/mu receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport.
Identification of the Fc-alpha/mu receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport.
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DOI：
10.1002/eji.202149383
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发表时间：
2021-11
影响因子：
5.4
通讯作者：
Flajnik MF
中科院分区：
文献类型：
--
作者：
Flowers EM;Neely HR;Guo J;Almeida T;Ohta Y;Castro CD;Flajnik MF
多聚免疫球蛋白受体（pIgR）通过粘膜上皮细胞转胞吞含J链的抗体。在哺乳动物中，PIGR的两个顺式重复，FCMR和FCAMR位于PIGR基因的侧翼。PIGR重复首先在两栖动物中发现，先前注释为PIGR 2（本文中为xIFCAMR），并且由抗原呈递细胞表达。我们证明xlFcamR是哺乳动物FcamR的等价物。人们一直认为pIgR是这个家族中最古老的成员，但我们的数据无法区分PIGR或FCAMR是否首先出现;然而，FCMR是最后出现的家族成员。有趣的是，硬骨鱼'pIgR'不是四足动物pIgR的直系同源物，并且可能通过趋同进化获得其功能。PIGR/FCAMR/FCMR是包括TREM、CD 300和NKp 44的更大超家族的成员，我们将其命名为“双二硫键IG超家族”（ddIgSF）。与每个ddIgSF家族相关的结构域在软骨鱼（鲨鱼、嵌合体）中被鉴定，并在与人pIgR基因座同线的单个基因簇中编码。因此，ddIgSF家族可以追溯到最早的基于抗体的适应性免疫，但显然不是在此之前。最后，我们的数据有力地表明，J链出现在进化中，只为IG多聚化。本研究为进一步研究pIgR和ddIgSF在脊椎动物中的作用奠定了基础。系统发育，功能和共线分析重塑我们对抗体转胞吞作用和相关受体的理解。典型的多聚免疫球蛋白受体（pIgR）首先出现在两栖动物中，与FcamR同时出现，而我们认为J链最初出现用于抗体多聚化。
The poly-Immunoglobulin Receptor (pIgR) transcytoses J chain-containing antibodies through mucosal epithelia. In mammals, two cis-duplicates of PIGR, FCMR and FCAMR, flank the PIGR gene. A PIGR duplication is first found in amphibians, previously annotated as PIGR2 (herein xlFCAMR), and is expressed by antigen-presenting cells. We demonstrate that xlFcamR is the equivalent of mammalian FcamR. It has been assumed that pIgR is the oldest member of this family, yet our data could not distinguish whether PIGR or FCAMR emerged first; however, FCMR was the last family member to emerge. Interestingly, bony fish ‘pIgR’ is not an orthologue of tetrapod pIgR, and possibly acquired its function via convergent evolution. PIGR/FCAMR/FCMR are members of a larger superfamily including TREM, CD300, and NKp44, which we name the ‘double-disulfide Ig superfamily’ (ddIgSF). Domains related to each ddIgSF family were identified in cartilaginous fish (sharks, chimeras) and encoded in a single gene cluster syntenic to the human pIgR locus. Thus, the ddIgSF families date back to earliest antibody-based adaptive immunity, but apparently not before. Finally, our data strongly suggest that the J chain arose in evolution only for Ig multimerization. This study provides a framework for further studies of pIgR and the ddIgSF in vertebrates. Phylogenetic, functional, and syntenic analysis reshape our understanding of antibody transcytosis and related receptors. The canonical poly-Immunoglobulin Receptor (pIgR) emerged first in amphibians, concurrent with FcamR, while we suggest J chain emerged initially for antibody multimerization.
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DOI：
10.1038/nrg2703
发表时间：
2010-01
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Cantoni, C;Ponassi, M;Bordo, D
通讯作者：
Bordo, D
影响因子：
5.4
作者：
Ghumra, Ashfaq;Shi, Jianguo;Mcintosh, Richard S.;Rasmussen, Ingunn B.;Braathen, Ranveig;Johansen, Finn-Eirik;Sandlie, Inger;Mongini, Patricia K.;Areschoug, Thomas;Lindahl, Gunnar;Lewis, Melanie J.;Woof, Jenny M.;Pleass, Richard J.
通讯作者：
Pleass, Richard J.
影响因子：
3.6
作者：
Hohman, VS;Stewart, SE;Steiner, LA
通讯作者：
Steiner, LA
影响因子：
64.8
作者：
Bouchon, A;Facchetti, F;Colonna, M
通讯作者：
Colonna, M