Origin and evolution of the adaptive immune system: genetic events and selective pressures.
Origin and evolution of the adaptive immune system: genetic events and selective pressures.
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DOI：
10.1038/nrg2703
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发表时间：
2010-01
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影响因子：
--
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中科院分区：
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哺乳动物的适应性免疫系统（AIS）主要是由携带抗原受体的淋巴细胞通过体细胞重组产生的，大约5亿年前出现在有颌鱼中。这种复杂的防御系统由许多分子，机制和组织组成，这些都不存在于无颌脊椎动物中。两个宏观进化事件被认为有助于AIS的发生：重组激活基因（RAG）转座子的出现和两轮全基因组复制。它最近被发现，一个非RAG为基础的AIS与有颌脊椎动物AIS的相似性-包括两个淋巴细胞谱系-出现在无颌鱼的趋同进化。我们提供的见解在这一领域的最新进展，并推测选择性的压力，导致了AIS的出现和维护。
The adaptive immune system (AIS) in mammals, which is centred on lymphocytes bearing antigen receptors that are generated by somatic recombination, arose approximately 500 million years ago in jawed fish. This intricate defence system consists of many molecules, mechanisms and tissues that are not present in jawless vertebrates. Two macroevolutionary events are believed to have contributed to the genesis of the AIS: the emergence of the recombination-activating gene (RAG) transposon, and two rounds of whole-genome duplication. It has recently been discovered that a non-RAG-based AIS with similarities to the jawed vertebrate AIS — including two lymphoid cell lineages — arose in jawless fish by convergent evolution. We offer insights into the latest advances in this field and speculate on the selective pressures that led to the emergence and maintenance of the AIS.
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影响因子：
3.2
作者：
Azumi, K;De Santis, R;Nonaka, M
通讯作者：
Nonaka, M
DOI：
10.1073/pnas.0811283106
发表时间：
2009-05-26
影响因子：
11.1
作者：
Chen, Hao;Kshirsagar, Sarika;Marchalonis, John J.
通讯作者：
Marchalonis, John J.
影响因子：
30.5
作者：
Alder, Matthew N.;Herrin, Brantley R.;Cooper, Max D.
通讯作者：
Cooper, Max D.
影响因子：
9.8
作者：
Belov K;Deakin JE;Papenfuss AT;Baker ML;Melman SD;Siddle HV;Gouin N;Goode DL;Sargeant TJ;Robinson MD;Wakefield MJ;Mahony S;Cross JG;Benos PV;Samollow PB;Speed TP;Graves JA;Miller RD
通讯作者：
Miller RD
影响因子：
7
作者：
Friedman, R;Hughes, AL
通讯作者：
Hughes, AL