Coproduction of polymalic acid and liamocins from two waste by-products from the xylitol and gluconate industries by Aureobasidium pullulans
Coproduction of polymalic acid and liamocins from two waste by-products from the xylitol and gluconate industries by Aureobasidium pullulans
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出芽短梗霉利用木糖醇和葡萄糖酸工业的两种废弃副产品联产聚苹果酸和利亚莫星
DOI：
10.1007/s00449-021-02578-8
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Xiang Zou
中科院分区：
文献类型：
--
作者：
Tianfu Li;Wenwen Yang;Xinran Xu;Yan Zhang;Jie Chen;Xiang Zou
在摇瓶和发酵罐中研究了出芽短梗霉分泌的两种重要代谢物聚苹果酸 (PMA) 和利阿莫星 (liamocins) 的联产，这些代谢物来自木糖醇和葡萄糖酸工业的两种废弃副产品，证实废木糖母液 (WXML) 无需任何预处理即可用作经济的原料。葡萄糖酸可以增强碳通量和 NADPH 供应，用于 PMA 和利莫星的协同生物合成。在分批发酵中，从偶联的 WXML 和葡萄糖酸废母液 (WGML) 中获得的 PMA 和利亚莫星滴度分别为 82.9 ± 2.1 和 28.3 ± 2.7 g/L，产量分别为 0.84 和 0.25 g/g。这些结果与从可再生原料获得的结果相当。该工艺的经济评估显示，PMA 和利莫星可以由两种副产品联产，成本为 1.48 美元/千克或 0.67 美元/千克（利莫星信用），为废物副产品的应用提供了一种经济且可持续的工艺。
The coproduction of polymalic acid (PMA) and liamocins, two important metabolites secreted by Aureobasidium pullulans, from two waste by-products from the xylitol and gluconate industries was investigated in shake flasks and fermentors, confirming that waste xylose mother liquor (WXML) could be utilized as an economical feedstock without any pretreatment. Gluconate could strengthen carbon flux and NADPH supply for the synergetic biosynthesis of PMA and liamocins. High PMA and liamocin titers of 82.9 ± 2.1 and 28.3 ± 2.7 g/L, respectively, were obtained from the coupled WXML and waste gluconate mother liquor (WGML) in batch fermentation, with yields of 0.84 and 0.25 g/g, respectively. These results are comparable to those obtained from renewable feedstocks. Economic assessment of the process revealed that PMA and liamocins could be coproduced from two by-products at costs of $1.48/kg or $0.67/kg (with liamocins credit), offering an economic and sustainable process for the application of waste by-products.
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DOI：
--
发表时间：
--
期刊：
--
影响因子：
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作者：
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影响因子：
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作者：
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