Food cue reactivity in successful laparoscopic gastric banding: A sham-deflation-controlled pilot study.
Food cue reactivity in successful laparoscopic gastric banding: A sham-deflation-controlled pilot study.
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DOI：
10.3389/fnhum.2022.902192
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
腹腔镜可调节胃束带（LAGB）提供了一个独特的机会来检查手术辅助减肥的潜在神经机制，因为它的即时，非侵入性，可调节的性质。6名体重稳定减轻的参与者（%EWL≥45）在LAGB手术后1.5-5年完成了2天的fMRI扫描。在受试者内随机假对照设计中，参与者接受（假）去除~ 50%的手环液体。与假收缩（即正常的束带收缩）相比，在收缩（即限制减少）条件下，受试者对食物图像的前扣带、角回、枕侧皮质和额叶皮质的激活明显降低（p < 0.05，全脑tfe -based FWE校正）。在收缩状态下，梭状回、颞下回、舌回和枕侧皮质的激活程度较高。这项研究的结果表明，通过LAGB收缩胃可能会间接改变大脑对食物线索的反应。这些神经元的变化可能是对食物的渴望和食物偏好的变化的基础，这些变化支持手术后持续的减肥。尽管样本量小，但这与越来越多的关于减肥手术后行为和控制区域变化的文献一致，并增加了这些文献。
Laparoscopic adjustable gastric banding (LAGB) offers a unique opportunity to examine the underlying neuronal mechanisms of surgically assisted weight loss due to its instant, non-invasive, adjustable nature. Six participants with stable excess weight loss (%EWL ≥ 45) completed 2 days of fMRI scanning 1.5–5 years after LAGB surgery. In a within-subject randomized sham-controlled design, participants underwent (sham) removal of ∼ 50% of the band’s fluid. Compared to sham-deflation (i.e., normal band constriction) of the band, in the deflation condition (i.e., decreasing restriction) participants showed significantly lower activation in the anterior (para)cingulate, angular gyrus, lateral occipital cortex, and frontal cortex in response to food images (p < 0.05, whole brain TFCE-based FWE corrected). Higher activation in the deflation condition was seen in the fusiform gyrus, inferior temporal gyrus, lingual gyrus, lateral occipital cortex. The findings of this within-subject randomized controlled pilot study suggest that constriction of the stomach through LAGB may indirectly alter brain activation in response to food cues. These neuronal changes may underlie changes in food craving and food preference that support sustained post-surgical weight-loss. Despite the small sample size, this is in agreement with and adds to the growing literature of post-bariatric surgery changes in behavior and control regions.
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DOI：
10.1002/oby.21464
发表时间：
2016-05
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Faulconbridge LF;Ruparel K;Loughead J;Allison KC;Hesson LA;Fabricatore AN;Rochette A;Ritter S;Hopson RD;Sarwer DB;Williams NN;Geliebter A;Gur RC;Wadden TA
通讯作者：
Wadden TA
影响因子：
--
作者：
Jo HJ;Gotts SJ;Reynolds RC;Bandettini PA;Martin A;Cox RW;Saad ZS
通讯作者：
Saad ZS
影响因子：
3.5
作者：
Gorgolewski KJ;Varoquaux G;Rivera G;Schwarz Y;Ghosh SS;Maumet C;Sochat VV;Nichols TE;Poldrack RA;Poline JB;Yarkoni T;Margulies DS
通讯作者：
Margulies DS
影响因子：
1.9
作者：
LaBar, KS;Gitelman, DR;Mesulam, MM
通讯作者：
Mesulam, MM
影响因子：
3.1
作者：
Ness, Abigail;Bruce, Jared;Savage, Cary R.
通讯作者：
Savage, Cary R.