Dietary Anthocyanins against Obesity and Inflammation.
Dietary Anthocyanins against Obesity and Inflammation.
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DOI：
10.3390/nu9101089
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发表时间：
2017-10-01
期刊：
影响因子：
5.9
通讯作者：
Yeum KJ
中科院分区：
文献类型：
--
作者：
Lee YM;Yoon Y;Yoon H;Park HM;Song S;Yeum KJ
慢性低度炎症在肥胖症的发病机制中起着关键作用，这是由于其相关的慢性疾病如II型糖尿病、心血管疾病、肺部疾病和癌症。因此，靶向炎症是对抗肥胖引起的健康问题负担的有吸引力的策略。最近，食物来源的生物活性化合物由于其低毒性而成为对抗各种慢性疾病的调节剂，而不是引起严重副作用的药物。在这里，我们描述了膳食花青素对肥胖引起的代谢紊乱和炎症的有益作用。红甘蓝微绿、蓝莓、黑醋栗、桑葚、樱桃、黑接骨木果、黑豆、chokeberry和jaboticaba果皮含有多种花青素，包括矢车菊素、飞燕草素、锦葵素、天竺葵素、芍药素和矮牵牛素，并且已报道改变细胞、动物和人类中的代谢标志物和炎症标志物。这篇综述讨论了炎症和肥胖之间的相互作用，以及随后通过使用膳食花青素进行调节，提出了一种替代的饮食策略来改善肥胖和肥胖相关的慢性疾病。
Chronic low-grade inflammation plays a pivotal role in the pathogenesis of obesity, due to its associated chronic diseases such as type II diabetes, cardiovascular diseases, pulmonary diseases and cancer. Thus, targeting inflammation is an attractive strategy to counter the burden of obesity-induced health problems. Recently, food-derived bioactive compounds have been spotlighted as a regulator against various chronic diseases due to their low toxicity, as opposed to drugs that induce severe side effects. Here we describe the beneficial effects of dietary anthocyanins on obesity-induced metabolic disorders and inflammation. Red cabbage microgreen, blueberry, blackcurrant, mulberry, cherry, black elderberry, black soybean, chokeberry and jaboticaba peel contain a variety of anthocyanins including cyanidins, delphinidins, malvidins, pelargonidins, peonidins and petunidins, and have been reported to alter both metabolic markers and inflammatory markers in cells, animals, and humans. This review discusses the interplay between inflammation and obesity, and their subsequent regulation via the use of dietary anthocyanins, suggesting an alternative dietary strategy to ameliorate obesity and obesity associated chronic diseases.
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