PACAPergic Synaptic Signaling and Circuitry Mediating Mammalian Responses to Psychogenic and Systemic Stressors

PACAPergic Synaptic Signaling and Circuitry Mediating Mammalian Responses to Psychogenic and Systemic Stressors
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PACAPergic 突触信号传导和电路介导哺乳动物对心因性和全身性应激源的反应

DOI:
10.1007/978-3-319-35135-3_41
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发表时间:
2016
影响因子:
3.4
通讯作者:
L. Eiden
L. Eiden
中科院分区:
医学3区
文献类型:
--
作者:
S. Z. Jiang;L. Eiden

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这篇简短的评论集中在中央和外周功能神经解剖的PACAP Pergic电路介导的压力反应,我们在这里定义为“电路介导的儿茶酚胺和皮质酮的海拔在响应系统性和心因性的压力,”和潜在的细胞信号传导途径,只要他们是已知的,通过它的PACAP信号在压力发生。我们将专注于潜在的神经生物学的PACAP信号来自啮齿动物的研究,并在人类和啮齿动物细胞培养的压力,并考虑其相关性PACAPergic神经传递在人类焦虑,抑郁症和创伤后应激障碍(PTSD)。
This short review is focused on the central and peripheral functional neuroanatomy of PACAPergic circuitry mediating stress responses, which we define here as “circuits mediating catecholamine and corticosterone elevation in response to systemic and psychogenic stressors,” and the underlying cell signaling pathways, insofar as they are known, through which PACAP signaling in stress occurs. We will focus on the underlying neurobiology of PACAP signaling in stress derived from studies in rodents, and in human and rodent cells in culture, and consider their relevance to PACAPergic neurotransmission in human anxiety, depression, and posttraumatic stress disorder (PTSD).
DOI: 10.1152/ajpcell.00001.2014
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