Clinical Applications of Magnetic Resonance Spectroscopy in Brain Tumors: From Diagnosis to Treatment.
Clinical Applications of Magnetic Resonance Spectroscopy in Brain Tumors: From Diagnosis to Treatment.
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DOI：
10.1016/j.rcl.2021.01.004
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发表时间：
2021-05
影响因子：
1.9
通讯作者：
Mullins ME
中科院分区：
文献类型：
--
作者：
Weinberg BD;Kuruva M;Shim H;Mullins ME
磁共振波谱（MRS）是一种将核磁共振（NMR）区分分子的能力与磁共振成像（MRI）特有的定位成像特征相结合的技术。这提供了一个“分子窗口”到给定组织的成分化学，允许独特的洞察生理或疾病（病理生理）过程。MRS不需要注射造影剂，也不涉及电离辐射，这是明显的安全性益处。已经探索了MRS在脑肿瘤成像中的许多应用，其中一些已经达到临床实践，另一些主要限于研究应用（表1）。在临床应用中，MRS可能将原发性脑肿瘤与其他潜在的拟态疾病（如脱髓鞘疾病、淋巴瘤或感染）区分开来。此外，高级别和低级别肿瘤的“分子特征”通常不同，从而可以预测肿瘤的侵袭性。治疗后，MRS可以提供洞察治疗组织是否主要由放射性坏死或肿瘤，一个相当大的诊断困境。更多以研究为导向的应用包括使用高分辨率全脑光谱MRI测量肿瘤以定位最具侵略性的区域，以进行活检和放射治疗。
Magnetic resonance spectroscopy (MRS) is a technique which combines the ability of nuclear magnetic resonance (NMR) to differentiate molecules with the imaging features of localization unique to magnetic resonance imaging (MRI). This provides a “molecular window” into the component chemistry of a given tissue, allowing for unique insight into physiologic or disease (pathophysiologic) processes. MRS requires no injected contrast agent and no ionizing radiation is involved, which are obvious safety benefits.There are many applications of MRS to imaging of brain tumors which have been explored, some of which have already reached clinical practice and others which have been confined predominantly to research applications (Table 1). In clinical application, MRS can potentially differentiate primary brain tumors from other potential mimics, such as demyelinating disease, lymphoma, or infection. Additionally, the “molecular signatures” of high-grade and low-grade tumors often differ, allowing prediction of how aggressive a tumor may be. After treatment, MRS can provide insight into whether treated tissue consists predominantly of radiation necrosis or tumor, a considerable diagnostic dilemma. More research-oriented applications include surveying a tumor to locate the most aggressive area to target for biopsy and radiation therapy using high resolution whole brain spectroscopic MRI.
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DOI：
10.1102/1470-7330.2006.0018
发表时间：
2006-09-07
期刊：
Cancer imaging : the official publication of the International Cancer Imaging Society
影响因子：
--
作者：
Fan G
通讯作者：
Fan G
DOI：
10.1073/pnas.82.7.2148
发表时间：
1985-01-01
影响因子：
11.1
作者：
BOTTOMLEY, PA;EDELSTEIN, WA;ADAMS, WA
通讯作者：
ADAMS, WA
影响因子：
15.9
作者：
Cordova, James S.;Shu, Hui-Kuo G.;Shim, Hyunsuk
通讯作者：
Shim, Hyunsuk
DOI：
10.1073/pnas.85.6.1821
发表时间：
1988-03-01
影响因子：
11.1
作者：
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通讯作者：
SHULMAN, RG
影响因子：
2.2
作者：
FRAHM, J;MERBOLDT, KD;HANICKE, W
通讯作者：
HANICKE, W