Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond.
Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond.
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人类心血管疾病中与氧化还原相关的生物标志物——经典印记及其他。
DOI：
10.1016/j.redox.2021.101875
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发表时间：
2021-06
期刊：
影响因子：
11.4
通讯作者：
Münzel T
中科院分区：
文献类型：
--
作者：
Daiber A;Hahad O;Andreadou I;Steven S;Daub S;Münzel T
全球流行病学研究表明，动脉粥样硬化和代谢紊乱等慢性非传染性疾病是过早死亡和发病的主要原因。心血管疾病，如缺血性心脏病，是全球疾病负担以及社会经济健康成本的主要促成因素。临床和流行病学数据显示，脂质过氧化产物、3 - 硝基酪氨酸或氧化的DNA/RNA碱基等典型氧化应激标志物与所有主要心血管疾病相关。这支持了这样一种概念，即由多种来源（NADPH氧化酶、黄嘌呤氧化酶和线粒体呼吸链）形成的活性氧和氮物质是高脂血症、高血压和糖尿病等主要心血管合并症的一个标志。这些活性氧和氮物质可导致氧化损伤，还会在激酶、钙处理、炎症、表观遗传控制、生物钟和蛋白酶体系统层面产生不良的氧化还原信号。本综述讨论了这些不良过程（氧化还原生物标志物）在体内的踪迹，重点关注其临床相关性，而其形成机制的细节和检测的技术方面仅简要提及。在合适示例的基础上，对氧化还原生物标志物的主要类别进行了总结和解释。还对氧化还原生物标志物的潜在预后价值进行了批判性讨论，以了解它们能提供何种信息以及它们无法实现什么。
全球疾病负担、氧化应激与心血管疾病（CVD）。
对心血管疾病中不同类别氧化还原生物标志物的讨论。
对人类心血管疾病中经典氧化应激标志物预后价值的讨论。
对人类心血管疾病中用于风险分层的新型氧化还原生物标志物的讨论。
强调氧化还原生物标志物在人类心血管疾病合并症中的累加性。
Global epidemiological studies show that chronic non-communicable diseases such as atherosclerosis and metabolic disorders represent the leading cause of premature mortality and morbidity. Cardiovascular disease such as ischemic heart disease is a major contributor to the global burden of disease and the socioeconomic health costs. Clinical and epidemiological data show an association of typical oxidative stress markers such as lipid peroxidation products, 3-nitrotyrosine or oxidized DNA/RNA bases with all major cardiovascular diseases. This supports the concept that the formation of reactive oxygen and nitrogen species by various sources (NADPH oxidases, xanthine oxidase and mitochondrial respiratory chain) represents a hallmark of the leading cardiovascular comorbidities such as hyperlipidemia, hypertension and diabetes. These reactive oxygen and nitrogen species can lead to oxidative damage but also adverse redox signaling at the level of kinases, calcium handling, inflammation, epigenetic control, circadian clock and proteasomal system. The in vivo footprints of these adverse processes (redox biomarkers) are discussed in the present review with focus on their clinical relevance, whereas the details of their mechanisms of formation and technical aspects of their detection are only briefly mentioned. The major categories of redox biomarkers are summarized and explained on the basis of suitable examples. Also the potential prognostic value of redox biomarkers is critically discussed to understand what kind of information they can provide but also what they cannot achieve. Global burden of disease, oxidative stress and cardiovascular disease (CVD). Discussion of the different categories of redox biomarkers in CVD. Discussion of prognostic value of classical oxidative stress markers in human CVD. Discussion of novel redox biomarkers for risk stratification in human CVD. Highlighting the additivity of redox biomarkers in human CVD comorbidities.
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影响因子：
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作者：
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通讯作者：
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