Race-ethnic differences in the association between lipid profile components and risk of myocardial infarction: The Northern Manhattan Study.
Race-ethnic differences in the association between lipid profile components and risk of myocardial infarction: The Northern Manhattan Study.
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DOI：
10.1016/j.ahj.2011.01.018
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发表时间：
2011-05
影响因子：
4.8
通讯作者：
Elkind, Mitchell S. V.
中科院分区：
文献类型：
--
作者：
Willey, Joshua Z.;Rodriguez, Carlos J.;Carlino, Richard F.;Moon, Yeseon Park;Paik, Myunghee C.;Boden-Albala, Bernadette;Sacco, Ralph L.;DiTullio, Marco R.;Homma, Shunichi;Elkind, Mitchell S. V.
目的：探讨血脂成分与心肌梗死发病风险之间的种族差异。作为曼哈顿北部研究的一部分，2738名没有心血管疾病的社区居民接受了前瞻性评估。采集基线空腹血样，并分析作为连续变量和分类变量的脂类成分。在调整人口统计学和心血管危险因素后，使用COX比例风险模型计算急性心肌梗死事件的危险比(HR)和95%可信区间(CI)。平均年龄为68.8±10.4岁；36.7%的男性，19.9%的非西班牙裔白人，24.9%的非西班牙裔黑人，52.8%的西班牙裔(超过80%来自加勒比海)。西班牙裔人群的平均高密度脂蛋白胆固醇水平较低，而甘油三酯/高密度脂蛋白胆固醇水平较高。在平均8.9年的随访期内，共发生163起失联事件。在整个队列中，所有的脂谱成分都在预期的方向上与心肌梗死的风险相关。然而，高密度脂蛋白胆固醇(调整后的心率每10 mg/dl增加0.93，95%可信区间0.76-1.12)和甘油三酯/高密度脂蛋白-C和甘油三酯/高密度脂蛋白-胆固醇和甘油三酯/高密度脂蛋白-C和甘油三酯/高密度脂蛋白-胆固醇每单位甘油三酯/高密度脂蛋白胆固醇增加与拉美裔美国人心肌梗死风险增加8%相关(调整后的HR为1.08，95%CI为1.04-1.12)。在西班牙裔人群中，低高密度脂蛋白胆固醇和甘油三酯/高密度脂蛋白胆固醇与心肌梗死风险无关。我们的数据表明，在拉美裔人群中，可能需要不同的甘油三酯/高密度脂蛋白比率来预测心肌梗死的风险。
To explore race-ethnic differences in the relationship between plasma lipid components and risk of incident myocardial infarction (MI). As part of the Northern Manhattan Study, 2738 community residents without cardiovascular disease were prospectively evaluated. Baseline fasting blood samples were collected and lipid panel components were analyzed as continuous and categorical variables. Cox proportional hazard models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for incident MI after adjusting for demographic and cardiovascular risk factors. The mean age was 68.8±10.4 years; 36.7% men, 19.9% non-Hispanic white, 24.9% non-Hispanic black, and 52.8% Hispanic (over 80% from the Caribbean). Hispanics had lower mean HDL-C, and higher TG/HDL-C. During a mean 8.9 years of follow-up there were 163 incident MIs. In the whole cohort all lipid profile components were associated with risk of MI in the expected directions. However, HDL-C (adjusted HR per 10 mg/dl increase 0.93, 95%CI 0.76–1.12) and TG/HDL-C>2 (adjusted HR 0.89, 95%CI 0.51–1.55) were not predictive of MI among Hispanics, but were predictive among non-Hispanic blacks and whites. TG/HDL-C per unit increase was associated with an 8% higher risk of MI among Hispanics (adjusted HR 1.08, 95%CI 1.04–1.12). In Hispanics, low HDL-C and TG/HDL-C>2 were not associated with MI risk. Our data suggests that a different TG/HDL ratio cutoff may be needed among Hispanics to predict MI risk.
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影响因子：
8.7
作者：
Haffner, SM;D'Agostino, R;Mykkänen, L
通讯作者：
Mykkänen, L
影响因子：
9.3
作者：
Li, Chaoyang;Ford, Earl S.;Reaven, Gerald M.
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作者：
Boden-Albala, Bernadette;Sacco, Ralph L.;Paik, Myunghee C.
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