Influence of cannabis use on incidence of psychosis in people at clinical high risk.
Influence of cannabis use on incidence of psychosis in people at clinical high risk.
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DOI：
10.1111/pcn.13555
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发表时间：
2023-09
影响因子：
11.9
通讯作者：
EU-GEI High Risk Study Group
中科院分区：
文献类型：
--
作者：
Chester LA;Valmaggia LR;Kempton MJ;Chesney E;Oliver D;Hedges EP;Klatsa E;Stahl D;van der Gaag M;de Haan L;Nelson B;McGorry P;Amminger GP;Riecher-Rössler A;Studerus E;Bressan R;Barrantes-Vidal N;Krebs MO;Glenthøj B;Nordentoft M;Ruhrmann S;Sachs G;McGuire P;EU-GEI High Risk Study Group
病例对照研究的证据表明，大麻的使用是精神病发展的一个危险因素。然而，前瞻性研究有限，这种关联的方向仍然存在争议。本研究的主要目的是研究大麻使用与临床精神病高危人群精神病发病率之间的关系。次要目的是评估大麻使用与精神病症状持续存在以及与功能预后之间的关系。使用修订版的《大麻体验问卷》，对临床精神病高风险个体（n = 334）和健康对照者（n = 67）目前和以前的大麻使用情况进行了评估。参与者在基线进行评估并随访2年。使用危险精神状态综合评估标准评估向精神病的转变和精神病症状的持续。使用功能障碍全球评估量表评估随访时的功能水平。随访期间，16.2%的临床高危人群出现精神病。在那些没有精神病的人中，51.4%的人有持续的症状，48.6%的人有缓解。在基线大麻使用的任何测量与向精神病的过渡、症状的持续或功能结果之间没有显著关联。这些发现与流行病学数据相反，流行病学数据表明大麻的使用增加了精神障碍的风险。
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome. Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n = 334) and healthy controls (n = 67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At-Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale. During follow up, 16.2% of the clinical high-risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome. These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder.
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DOI：
10.1016/s2215-0366(19)30048-3
发表时间：
2019-05
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Di Forti M;Quattrone D;Freeman TP;Tripoli G;Gayer-Anderson C;Quigley H;Rodriguez V;Jongsma HE;Ferraro L;La Cascia C;La Barbera D;Tarricone I;Berardi D;Szöke A;Arango C;Tortelli A;Velthorst E;Bernardo M;Del-Ben CM;Menezes PR;Selten JP;Jones PB;Kirkbride JB;Rutten BP;de Haan L;Sham PC;van Os J;Lewis CM;Lynskey M;Morgan C;Murray RM;EU-GEI WP2 Group
通讯作者：
EU-GEI WP2 Group
影响因子：
6.9
作者：
Buchy L;Cadenhead KS;Cannon TD;Cornblatt BA;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Heinssen R;Bearden CE;Mathalon D;Addington J
通讯作者：
Addington J
DOI：
10.1007/s00406-012-0305-z
发表时间：
2012-10-01
影响因子：
4.7
作者：
Carra, Giuseppe;Johnson, Sonia;Toumi, Mondher
通讯作者：
Toumi, Mondher
影响因子：
4.5
作者：
Corcoran, Cheryl M.;Kimhy, David;Malaspina, Dolores
通讯作者：
Malaspina, Dolores
影响因子：
6.6
作者：
Di Forti, Marta;Sallis, Hannah;Murray, Robin M.
通讯作者：
Murray, Robin M.