Diseased and healthy murine local lung strains evaluated using digital image correlation.
Diseased and healthy murine local lung strains evaluated using digital image correlation.
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DOI：
10.1038/s41598-023-31345-w
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发表时间：
2023-03-20
影响因子：
4.6
通讯作者：
Eskandari, M.
中科院分区：
文献类型：
--
作者：
Nelson, T. M.;Quiros, K. A. M.;Dominguez, E. C.;Ulu, A.;Nordgren, T. M.;Eskandari, M.
肺部疾病中的组织重塑会不可逆地改变肺功能并影响生活质量。机械通气是为数不多的帮助呼吸的肺部干预措施之一，但可能有害或致命，导致过度的局部（即局部）肺部劳损。先前的研究加深了对通气条件下患病的整体肺反应的理解，但没有充分捕捉关键的局部反应。在这里，我们将定制设计的压力-容量呼吸机与数字图像相关的新应用配对，以直接评估纤维化诱导的离体小鼠肺中的区域应变，并通过感兴趣的区域进行分析。我们讨论患病和健康肺力学之间的差异，例如扩张性、异质性、各向异性、肺泡募集和速率依赖性。值得注意的是，我们通过评估不同通气量和通气率产生的压力-应变和压力-容积曲线的演变来比较患病和健康状态之间的局部和整体依从性。我们发现纤维化的肺扩张能力较差，肺复张行为和区域应变发生改变，并且局部和整体顺应性之间表现出不同的行为。此外，这些患病特征显示出体积依赖性和发病率趋势。最终，我们证明了与健康肺相比，纤维化肺如何特别容易受到损伤，这有助于加深对呼吸机引起的肺损伤如何发展的理解。
Tissue remodeling in pulmonary disease irreversibly alters lung functionality and impacts quality of life. Mechanical ventilation is amongst the few pulmonary interventions to aid respiration, but can be harmful or fatal, inducing excessive regional (i.e., local) lung strains. Previous studies have advanced understanding of diseased global-level lung response under ventilation, but do not adequately capture the critical local-level response. Here, we pair a custom-designed pressure–volume ventilator with new applications of digital image correlation, to directly assess regional strains in the fibrosis-induced ex-vivo mouse lung, analyzed via regions of interest. We discuss differences between diseased and healthy lung mechanics, such as distensibility, heterogeneity, anisotropy, alveolar recruitment, and rate dependencies. Notably, we compare local and global compliance between diseased and healthy states by assessing the evolution of pressure-strain and pressure–volume curves resulting from various ventilation volumes and rates. We find fibrotic lungs are less-distensible, with altered recruitment behaviors and regional strains, and exhibit disparate behaviors between local and global compliance. Moreover, these diseased characteristics show volume-dependence and rate trends. Ultimately, we demonstrate how fibrotic lungs may be particularly susceptible to damage when contrasted to the strain patterns of healthy counterparts, helping to advance understanding of how ventilator induced lung injury develops.
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影响因子：
5.2
作者：
通讯作者：
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影响因子：
3.3
作者：
FINE, R;MCCULLOUGH, B;JOHANSON, WG
通讯作者：
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影响因子：
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作者：
Eskandari, Mona;Arvayo, Alberto L.;Levenston, Marc E.
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Levenston, Marc E.
影响因子：
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作者：
Ito, S;Ingenito, EP;Suki, B
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Suki, B
DOI：
10.1164/ajrccm.162.5.9907096
发表时间：
2000-11-01
影响因子：
24.7
作者：
Lansing, RW;Im, BSH;Banzett, RB
通讯作者：
Banzett, RB