A critical period for learning and plastic changes at hippocampal CA1 synapses.
A critical period for learning and plastic changes at hippocampal CA1 synapses.
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学习和海马CA1区突触可塑性变化的关键时期。
DOI：
10.1038/s41598-022-10453-z
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发表时间：
2022-05-03
影响因子：
4.6
通讯作者：
Mitsushima, Dai
中科院分区：
文献类型：
--
作者：
Sakimoto, Yuya;Shintani, Ako;Yoshiura, Daiki;Goshima, Makoto;Kida, Hiroyuki;Mitsushima, Dai
海马功能的出生后发育在许多哺乳动物物种中已有报道，包括人类。为了获得突触的证据，我们分析了大鼠在抑制性回避任务后可塑性的发育变化。婴儿（出生后2周）的学习表现较低，但从幼年期（3-4周）到成年期（8周）明显改善。训练后1 h，制备脑片，记录同一海马CA 1区神经元的兴奋性突触后电流（mEPSC）和抑制性突触后电流（mIPSC）。虽然训练在2周时未能影响mEPSC或mIPSC的振幅，但在3周时增加了mEPSC的振幅，但没有增加mIPSC的振幅。在4周时，训练增加了mEPSC和mIPSC的振幅，而mIPSC的振幅在8周时增加，而不是mEPSC。由于早期的生理功能会影响表现，我们还评估了感觉运动功能和情绪状态，发现从婴儿期到成年期都有足够的感觉/运动功能。此外，通过分析大鼠在多个任务中的表现，我们发现，在性能的发展变化是任务依赖性。总之，这些发现描绘了一个关键时期的学习和海马CA 1区突触的可塑性变化。
Postnatal development of hippocampal function has been reported in many mammalian species, including humans. To obtain synaptic evidence, we analyzed developmental changes in plasticity after an inhibitory avoidance task in rats. Learning performance was low in infants (postnatal 2 weeks) but clearly improved from the juvenile period (3–4 weeks) to adulthood (8 weeks). One hour after the training, we prepared brain slices and sequentially recorded miniature excitatory postsynaptic currents (mEPSCs) and inhibitory postsynaptic currents (mIPSCs) from the same hippocampal CA1 neuron. Although the training failed to affect the amplitude of either mEPSCs or mIPSCs at 2 weeks, it increased mEPSC, but not mIPSC, amplitude at 3 weeks. At 4 weeks, the training had increased the amplitude of both mEPSCs and mIPSCs, whereas mIPSC, but not mEPSC, amplitude was increased at 8 weeks. Because early-life physiological functions can affect performance, we also evaluated sensory–motor functions together with emotional state and found adequate sensory/motor functions from infancy to adulthood. Moreover, by analyzing performance of rats in multiple hippocampal-dependent tasks, we found that the developmental changes in the performance are task dependent. Taken together, these findings delineate a critical period for learning and plastic changes at hippocampal CA1 synapses.
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影响因子：
4.6
作者：
Takase K;Sakimoto Y;Kimura F;Mitsushima D
通讯作者：
Mitsushima D
DOI：
10.1073/pnas.89.10.4363
发表时间：
1992-05-15
影响因子：
11.1
作者：
DUDEK, SM;BEAR, MF
通讯作者：
BEAR, MF
影响因子：
3.7
作者：
Abada YS;Nguyen HP;Schreiber R;Ellenbroek B
通讯作者：
Ellenbroek B
ERK信号传导的神经纤维素调节调节GABA释放和学习。
影响因子：
64.5
作者：
Cui Y;Costa RM;Murphy GG;Elgersma Y;Zhu Y;Gutmann DH;Parada LF;Mody I;Silva AJ
通讯作者：
Silva AJ
影响因子：
2.7
作者：
Arrant, Andrew E.;Schramm-Sapyta, Nicole L.;Kuhn, Cynthia M.
通讯作者：
Kuhn, Cynthia M.