Developmental trajectory of contextual learning and 24-h acetylcholine release in the hippocampus.
Developmental trajectory of contextual learning and 24-h acetylcholine release in the hippocampus.
复制标题
DOI：
10.1038/srep03738
复制
发表时间：
2014-01-17
影响因子：
4.6
通讯作者：
Mitsushima D
中科院分区：
文献类型：
--
作者：
Takase K;Sakimoto Y;Kimura F;Mitsushima D
为了确定大鼠海马功能的发育轨迹，我们检测了24小时细胞外乙酰胆碱（ACh）水平和情境学习表现的变化。细胞外乙酰胆碱与自发行为显著相关，在幼年（4周龄）、青春期（6周龄）和成年（9- 12周龄）大鼠中表现出24小时的节律。尽管雌雄幼体均表现出较低的ACh水平，但成年雄性的ACh水平高于成年雌性。此外，当乙酰胆碱水平相等时，幼鱼表现出比成年鱼更多的自发活动。同样，雌雄幼体表现出相对较低的情境学习表现。由于语境学习成绩只有男性显著提高，成年男性表现出比成年女性更好的表现。我们还观察到上下文学习和乙酰胆碱水平之间的发展关系。东莨菪碱预处理阻断了上下文学习并中断了相关性。由于断奶后长期东莨菪碱治疗会损害幼鼠的情境学习，胆碱能输入可能参与海马的发育。
To determine the developmental trajectory of hippocampal function in rats, we examined 24-h changes in extracellular acetylcholine (ACh) levels and contextual learning performance. Extracellular ACh significantly correlated with spontaneous behavior, exhibiting a 24-h rhythm in juvenile (4-week-old), pubertal (6-week-old), and adult (9- to 12-week-old) rats. Although juveniles of both sexes exhibited low ACh levels, adult males had higher ACh levels than adult females. Moreover, juveniles exhibited much more spontaneous activity than adults when they showed equivalent ACh levels. Similarly, juveniles of both sexes exhibited relatively low contextual learning performance. Because contextual learning performance was significantly increased only in males, adult males exhibited better performance than adult females. We also observed a developmental relationship between contextual learning and ACh levels. Scopolamine pretreatment blocked contextual learning and interrupted the correlation. Since long-term scopolamine treatment after weaning impaired contextual learning in juveniles, the cholinergic input may participate in the development of hippocampus.
登录
查看更多内容
影响因子：
2.9
作者：
Chaddock L;Erickson KI;Prakash RS;Kim JS;Voss MW;Vanpatter M;Pontifex MB;Raine LB;Konkel A;Hillman CH;Cohen NJ;Kramer AF
通讯作者：
Kramer AF
影响因子：
25
作者：
Imayoshi, Itaru;Sakamoto, Masayuki;Kageyama, Ryoichiro
通讯作者：
Kageyama, Ryoichiro
影响因子：
3.4
作者：
Daniel, JM;Winsauer, PJ;Moerschbaecher, JM
通讯作者：
Moerschbaecher, JM
影响因子：
2.9
作者：
He, DQ;Mitsushima, D;Kimura, F
通讯作者：
Kimura, F
影响因子：
2.9
作者：
MAREN, S;DEOCA, B;FANSELOW, MS
通讯作者：
FANSELOW, MS