Health-related quality of life in Black breast cancer survivors with and without triple-negative breast cancer (TNBC).
Health-related quality of life in Black breast cancer survivors with and without triple-negative breast cancer (TNBC).
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患有和没有三阴性乳腺癌（TNBC）的黑乳腺癌幸存者的健康相关生活质量。
DOI：
10.1007/s10549-017-4173-0
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发表时间：
2017-06
影响因子：
3.8
通讯作者：
Pal T
中科院分区：
文献类型：
--
作者：
Vadaparampil ST;Christie J;Donovan KA;Kim J;Augusto B;Kasting ML;Holt CL;Ashing K;Halbert CH;Pal T
黑人女性更有可能患上早发性（≤50岁）乳腺癌（BC），并且在任何美国（美国）中具有最低的五年特定原因生存率。种族或民族群体。这些差异可部分归因于黑人的三阴性BC（TNBC）比率较高。然而，对患有TNBC的黑人妇女的健康相关生活质量（HRQOL）知之甚少。通过佛罗里达州癌症登记处招募了浸润性BC ≤50岁的黑人女性，作为早发浸润性BC病因学和结局的基于人群的仅病例研究的一部分。在460名知情同意的参与者中，收集了355个自我报告的社会人口统计学、临床和心理社会变量。描述性分析包括已知TNBC（n=85）或非TNBC（n=245）疾病的参与者。进行单变量和多变量分析，以检查与HRQOL相关的因素的差异。在未调整的分析中，与非TNBC参与者（98.5 ± 27.6）相比，TNBC参与者的FACT-B总分（90.1 ± 27.9）显著更低（p<0.05）。对于TNBC组，多变量分析表明，5个个体水平和3个系统水平的因素解释了HRQOL反应变异的80%。对于非TNBC组，7个个体水平因素和3个系统水平因素占HRQOL评分变化的76%。与非TNBC的黑人女性相比，TNBC女性的HRQOL更差。这两个群体都有独特的个人和系统层面的关键因素。调查结果可以为未来的HRQOL干预措施提供信息，以支持年轻的黑人BC幸存者。
Black women are more likely to develop early onset (≤50 years) breast cancer (BC) and have the lowest five-year, cause-specific survival rate of any United States (U.S.) racial or ethnic group. These disparities can be attributed partially to the higher rate of triple negative BC (TNBC) in Blacks. Yet, little is known about health-related quality of life (HRQOL) among Black women with TNBC. Black women with invasive BC ≤50 years were recruited via the Florida State Cancer Registry as part of a population-based case-only study of etiology and outcomes of early-onset invasive BC. Of 460 consented participants, a subset of 355 self-reported sociodemographic, clinical, and psychosocial variables were collected. Descriptive analyses included participants with known TNBC (n=85) or non-TNBC (n=245) disease. Univariable and multivariable analyses were conducted to examine differences in factors associated with HRQOL. In unadjusted analyses, TNBC participants had significantly lower FACT-B total scores (90.1 ± 27.9) compared to non-TNBC (98.5 ± 27.6) participants (p<0.05). For the TNBC group, multivariable analyses indicated five individual-level and three systemic-level factors explain 80% of the response variation in HRQOL. For the non-TNBC group, seven individual-level factors and three systemic-level factors account for 76% of the variation in HRQOL scores. Compared to Black women with non-TNBC, TNBC women have worse HRQOL. There are key individual and systemic-level factors that are unique to both groups. Findings can inform future HRQOL interventions to support young Black BC survivors.
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影响因子：
254.7
作者：
DeSantis, Carol E.;Fedewa, Stacey A.;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
45.3
作者：
Avis, NE;Crawford, S;Manuel, J
通讯作者：
Manuel, J
影响因子：
7.2
作者：
Eton, DT;Cella, D;Wood, WC
通讯作者：
Wood, WC
影响因子：
3.7
作者：
Miller, Aria M.;Ashing, Kimlin Tam;Sealy, Diadrey-Anne T.
通讯作者：
Sealy, Diadrey-Anne T.
DOI：
10.1111/tbj.12545
发表时间：
2016-03
期刊：
The breast journal
影响因子：
--
作者：
Bonner D;Cragun D;Reynolds M;Vadaparampil ST;Pal T
通讯作者：
Pal T