Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin.

Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin.
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DOI:
10.3389/fnins.2012.00194
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发表时间:
2012
影响因子:
4.3
通讯作者:
Macdonald KS
Macdonald KS
中科院分区:
医学2区
文献类型:
--
作者:
Macdonald KS

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正如本期特刊(MacDonald和Feifel)的大型评论中所讨论的那样,鼻内催产素(OT)作为精神病学治疗药物的潜力正在不断增长。重要的是,研究表明,各种个人因素可能会影响一个人对OT的反应。在这篇小型综述中,我提供了三个方面的综述:(1)性别和激素状态;(2)OT系统方面的遗传变异(即,OT受体);和(3)依恋史。这些因素中的每一个都将是重要的监测,因为我们努力发展更丰富的理解OT在人类发育中的作用,以脑为基础的疾病,以及个性化,OT靶向治疗的潜力。
As discussed in the larger review in this special issue (MacDonald and Feifel), intranasal oxytocin (OT) is demonstrating a growing potential as a therapeutic agent in psychiatry. Importantly, research suggests that a variety of individual factors may influence a person’s response to OT. In this mini-review, I provide a review of three: (1) sex and hormonal status; (2) genetic variation in aspects of the OT system (i.e., OT receptors); and (3) attachment history. Each of these factors will be important to monitor as we strive to develop a richer understanding of OT’s role in human development, brain-based disease, and the potential for individualized, OT-targeted treatments.
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