Atherosclerosis and transit of HDL through the lymphatic vasculature.
Atherosclerosis and transit of HDL through the lymphatic vasculature.
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DOI：
10.1007/s11883-013-0354-4
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发表时间：
2013-09
影响因子：
5.8
通讯作者：
Randolph, Gwendalyn J.
中科院分区：
文献类型：
--
作者：
Martel, Catherine;Randolph, Gwendalyn J.
已知驱动疾病进展的动脉粥样硬化斑块的关键组分是巨噬细胞和胆固醇。它已被广泛理解，并支持最近的证据，胆固醇流出巨噬细胞泡沫细胞平息疾病的进展，甚至促进退化。在巨噬细胞胆固醇流出后，必须从斑块环境中去除负载在HDL上的胆固醇。在这里，我们专注于最近的证据表明，淋巴管是至关重要的胆固醇，可能作为HDL的组成部分，从组织，包括皮肤和动脉壁。我们讨论了动脉粥样硬化的进展可能部分与斑块中胆固醇清除缓慢有关的可能性。
Key components of atherosclerotic plaque known to drive disease progression are macrophages and cholesterol. It has been widely understood, and bolstered by recent evidence, that the efflux of cholesterol from macrophage foam cells quells disease progression or even to promote regression. Following macrophage cholesterol efflux, cholesterol loaded onto HDL must be removed from the plaque environment. Here, we focus on recent evidence that the lymphatic vasculature is critical for the removal of cholesterol, likely as a component of HDL, from tissues including skin and the artery wall. We discuss the possibility that progression of atherosclerosis might in part be linked to sluggish removal of cholesterol from the plaque.
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影响因子：
15.9
作者：
Martel, Catherine;Li, Wenjun;Randolph, Gwendalyn J.
通讯作者：
Randolph, Gwendalyn J.
影响因子：
10.5
作者：
Johnson, Nicole C.;Dillard, Miriam E.;Oliver, Guillermo
通讯作者：
Oliver, Guillermo
影响因子：
158.5
作者：
Barter, Philip J.;Caulfield, Mark;Brewer, Bryan
通讯作者：
Brewer, Bryan
影响因子：
20.1
作者：
Meyer, G;Merval, R;Tedgui, A
通讯作者：
Tedgui, A
影响因子：
32.4
作者：
Chang SY;Song JH;Guleng B;Cotoner CA;Arihiro S;Zhao Y;Chiang HS;O'Keeffe M;Liao G;Karp CL;Kweon MN;Sharpe AH;Bhan A;Terhorst C;Reinecker HC
通讯作者：
Reinecker HC