Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal.
Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal.
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DOI：
10.3389/fimmu.2017.01743
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发表时间：
2017
影响因子：
7.3
通讯作者：
Rothlin CV
中科院分区：
文献类型：
--
作者：
Hughes LD;Bosurgi L;Ghosh S;Rothlin CV
大量的细胞周转通过细胞凋亡发生在我们的组织在恒定的重塑中，从暴露在屏障表面的细胞脱落到自身反应性淋巴细胞的消除。然而，凋亡细胞的激增也伴随着组织损伤、感染和炎症。在这两种情况下，细胞凋亡的一个显著特征是磷脂酰丝氨酸（PtdSer）暴露在质膜的外小叶上。为了响应这一提示，一系列吞噬细胞承担了吞噬凋亡小体和处理每天死亡的数十亿细胞的艰巨任务。凋亡细胞在上述明显不同的免疫环境中存在，因此，提出了一个问题，即吞噬细胞如何能够协调对凋亡细胞的适当反应——从它们的沉默清除到生长因子或组织修复分子的产生——在PtdSer暴露等无处不在的信号下。在这里，我们考虑了吞噬细胞和凋亡细胞清除的几个紧急特性，这些特性可能有助于规范这一系列潜在反应。
Massive turnover of cells occurs through apoptosis during the constant remodeling of our tissues at homeostasis, from the shedding of cells at exposed barrier surfaces to the elimination of autoreactive lymphocytes. However, a surge of apoptotic cells also accompanies tissue damage, infection, and inflammation. A salient feature of apoptosis in either scenario is the exposure of phosphatidylserine (PtdSer) on the outer leaflet of the plasma membrane. In response to this cue, a range of phagocytes are charged with the sizeable task of engulfing apoptotic bodies and disposing of the billions of cells that perish each day. The presence of apoptotic cells in the remarkably distinct immunological settings described above, therefore, raises the question of how phagocytes are able to coordinate appropriate responses to apoptotic cells—from their silent removal to the production of growth factors or tissue repair molecules—following such a ubiquitous signal as PtdSer exposure. Here, we consider several emergent properties of phagocytes and apoptotic cell clearance that may facilitate specification among this suite of potential responses.
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DOI：
10.1126/science.aaj2067
发表时间：
2017-06-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Minutti CM;Jackson-Jones LH;García-Fojeda B;Knipper JA;Sutherland TE;Logan N;Ringqvist E;Guillamat-Prats R;Ferenbach DA;Artigas A;Stamme C;Chroneos ZC;Zaiss DM;Casals C;Allen JE
通讯作者：
Allen JE
影响因子：
15.9
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM
DOI：
10.1073/pnas.1507625112
发表时间：
2015-07-14
影响因子：
11.1
作者：
Moshkovits, Itay;Karo-Atar, Danielle;Munitz, Ariel
通讯作者：
Munitz, Ariel
影响因子：
4.4
作者：
Byrne, A;Reen, DJ
通讯作者：
Reen, DJ
影响因子：
82.9
作者：
通讯作者：
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