Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia.
Assessment of red blood cell distribution width as a prognostic marker in chronic lymphocytic leukemia.
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DOI：
10.18632/oncotarget.9055
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发表时间：
2016-05-31
期刊：
影响因子：
--
通讯作者：
Darzynkiewicz Z
中科院分区：
文献类型：
--
作者：
Podhorecka M;Halicka D;Szymczyk A;Macheta A;Chocholska S;Hus M;Darzynkiewicz Z
红细胞分布宽度（RDW）是循环红细胞大小变异性的定量测量。近年来研究表明，RDW是感染性疾病、心血管疾病、肺部疾病以及某些肿瘤的预后因子。此外，RDW是45岁及以上成年人寿命（包括所有死亡原因）的强有力预测因素。为了解释这种情况，有人提出，持续的IGFs/mTOR信号传导是影响RDW和死亡率的因素之一。上述观察促使我们分析RDW在慢性淋巴细胞白血病（CLL）中的预后作用，慢性淋巴细胞白血病是西方国家最常见的成人白血病类型。所获得的结果表明，RDW可能被认为是一个潜在的CLL预后标志物。诊断时RDW水平升高与晚期疾病和其他不良预后因素的存在相关。它还与总生存期有关，表明RDW升高的患者的生存时间较短。目前观察到的CLL患者的死亡率和RDW之间的相关性可能受到其代谢（IGF-1/mTOR驱动）而不是时间老化的影响。具有高水平RDW的患者预期具有增加的IGF-1/mTOR信号传导的持续水平。因此，在个性化治疗的框架内，这些CLL患者预计对mTOR抑制剂治疗更敏感。
Red blood cell distribution width (RDW) is a quantitative measure of the variability in size of circulating erythrocytes. It was recently reported that RDW is a prognostic factor for infection diseases, cardiovascular and pulmonary diseases, as well as some neoplasms. Moreover, RDW is remarkably strong predictor of longevity, including all causes of death, for adults aged 45 years and older. To explain this occurrence it was proposed that persistent IGFs/mTOR signaling is one of the factors that play a role in affecting the RDW and mortality. The above observations induced us to analyze the prognostic role of RDW in chronic lymphocytic leukemia (CLL) being the most frequent type of adult leukemia in Western countries. The obtained results have shown that RDW may be considered as a potential CLL prognostic marker. Elevated RDW level at the moment of diagnosis was associated with advanced disease and presence of other poor prognostic factors. It is also connected with overall survival indicating shorter time in patients with elevated RDW. It is possible that the presently observed correlation between mortality and RDW of the CLL patients is affected by their metabolic (IGF-1/mTOR driven)- rather than chronological- aging. The patients with high level of RDW are expected to have an increased persistent level of IGF-1/mTOR signaling. Within the framework of personalized therapy, these CLL patients therefore would be expected to be more sensitive to the treatment with mTOR inhibitors.
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影响因子：
6.2
作者：
Anisimov, Vladimir N.;Bartke, Andrzej
通讯作者：
Bartke, Andrzej
影响因子：
12.8
作者：
Hallek, Michael
通讯作者：
Hallek, Michael
DOI：
10.18632/aging.100521
发表时间：
2012-12
期刊：
Aging
影响因子：
--
作者：
Halicka HD;Zhao H;Li J;Lee YS;Hsieh TC;Wu JM;Darzynkiewicz Z
通讯作者：
Darzynkiewicz Z
影响因子：
6
作者：
Allen, Larry A.;Felker, G. Michael;Mehra, Mandeep R.;Chiong, Jun R.;Dunlap, Stephanie H.;Ghali, Jalal K.;Lenihan, Daniel J.;Oren, Ron M.;Wagoner, Lynne E.;Schwartz, Todd A.;Adams, Kirkwood F., Jr.
通讯作者：
Adams, Kirkwood F., Jr.
影响因子：
158.5
作者：
Crespo, M;Bosch, F;Montserrat, E
通讯作者：
Montserrat, E