Systematic review of proinflammatory cytokines in obsessive-compulsive disorder.
Systematic review of proinflammatory cytokines in obsessive-compulsive disorder.
复制标题
对强迫症的促炎细胞因子的系统评价。
DOI：
10.1007/s11920-012-0272-0
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发表时间：
2012-06
影响因子：
6.7
通讯作者：
Bloch, Michael H.
中科院分区：
文献类型：
--
作者：
Gray, Simon M.;Bloch, Michael H.
关键词：
几项研究检测了促炎细胞因子的水平，如肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β和IL-6。这项荟萃分析旨在研究强迫症（OCD）与促炎细胞因子血浆血清水平之间的相关性。12项研究符合纳入标准。荟萃分析显示，OCD患者的IL-1β水平显著降低。血浆IL-6或TNF-α水平无显著差异。分层亚组分析显示年龄和药物使用对IL-6水平可能有调节作用。包括儿童精神药物治疗的研究显示血浆IL-6水平较低。分层亚组分析显示共病抑郁对TNF-α水平的调节作用。在包括患有抑郁症的个体的研究中报告了TNF-α水平升高。未来的研究检查免疫功能的强迫症应调整潜在的混淆，由于药物使用和共病抑郁症。还需要进一步研究评估强迫症患者脑脊液细胞因子水平。
Several studies have examined levels of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. This meta-analysis was conducted to examine the association between obsessive-compulsive disorder (OCD) and plasma serum levels of proinflammatory cytokines. Twelve studies met inclusion criteria. The meta-analysis demonstrated a significant reduction in IL-1β levels in OCD. No significant difference in plasma levels of IL-6 or TNF-α was demonstrated. Stratified subgroup analysis revealed possible moderating effects of age and medication use on IL-6 levels. Studies including children on psychotropic medication had lower plasma IL-6 levels. Stratified subgroup analysis revealed a moderating effect of comorbid depression on TNF-α levels. Elevated TNF-α levels were reported in studies that included individuals with comorbid depression. Future studies examining immune function in OCD should adjust for potential confounding due to medication use and comorbid depression. Further studies assessing cerebrospinal fluid cytokine levels in OCD are also needed.
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