Thalamic post-inhibitory bursting occurs in patients with organic dystonia more often than controls.
Thalamic post-inhibitory bursting occurs in patients with organic dystonia more often than controls.
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器质性肌张力障碍患者的丘脑抑制后爆发比对照组更常见。
DOI：
10.1016/j.brainres.2013.10.006
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发表时间：
2013-12-06
期刊：
影响因子：
2.9
通讯作者：
Lenz, F. A.
中科院分区：
文献类型：
--
作者：
Kobayashi, K.;Liu, C. C.;Jensen, A. L.;Vitek, J. L.;Mari, Z.;Lenz, F. A.
我们现在检验这样的假设：人类丘脑苍白球接收核（腹侧口腔）的抑制后爆发介导肌张力障碍期间抑制性苍白球丘脑传递。我们将九名器质性肌张力障碍患者的丘脑单神经元活动与心因性肌张力障碍（Psyd）患者和健康清醒猴子的丘脑单神经元活动进行了比较。在器质性肌张力障碍中，肌电图功率通常集中在平滑自动功率谱的最低频率 (0.39Hz)。因此，0.39 Hz 时信噪比≥ 2 的尖峰序列片段被称为肌张力障碍频率 (DF) 片段，这种情况在与运动相关的肌张力障碍期间更常见。 SNR < 2 的节段被称为非肌张力障碍频率 (nDF) 节段，与自发性肌张力障碍相关。我们专注于 nDF 活动，因为对照组的神经元活动是在休息时测量的。神经元尖峰序列分为抑制后爆发（G，分组）、单尖峰（NG，未分组）或同时具有单尖峰和爆发（I，中间）。肌张力障碍患者腹侧口部的 nDF 尖峰序列比对照组有更多的 G 类放电。器质性肌张力障碍的 nDF 放电的爆发率和爆发前静默期始终高于猴子和精神病患者。爆发前沉默期的分布是双峰的，具有大约 GABAb（γ 氨基丁酸受体 - b 型）持续时间的较长模式。这些结果表明器质性肌张力障碍与对照组的抑制后爆发存在明显差异。与 GABAb 持续时间一致的抑制事件的存在表明肌张力障碍的治疗干预措施。
We now test the hypothesis that post-inhibitory bursting in the human pallidal receiving nucleus of the thalamus (ventral oral) mediates inhibitory pallido-thalamic transmission during dystonia. We have compared thalamic single neuron activity in nine patients with organic dystonia to that in a patient with psychogenic dystonia (Psyd) and in healthy waking monkeys. In organic dystonia, EMG power is commonly concentrated at the lowest frequency of the smoothed autopower spectrum (0.39Hz). Therefore, segments of spike trains with a signal-to-noise ratio ≥ 2 at 0.39 Hz were termed dystonia frequency (DF) segments, which occurred more commonly during dystonia related to movement. Those with a SNR < 2 were termed non-dystonia frequency (nDF) segments, which are associated with spontaneous dystonia. We concentrated on nDF activity since neuronal activity in our controls was measured at rest. Neuronal spike trains were categorized into those with post-inhibitory bursts (G, grouped), with single spikes (NG, non-grouped), or with both single spikes and bursts (I, intermediate). nDF spike trains in ventral oral had more G category firing in dystonia than in controls. The burst rate and the pre-burst silent period in nDF firing of organic dystonia were consistently greater than those of both the monkeys and the patient with Psyd. The distribution of the pre-burst silent period was bimodal with a longer mode of approximately GABAb (gamma amino butyric acid receptor - type b) duration. These results demonstrate distinct differences of post-inhibitory bursting in organic dystonia versus controls. The presence of inhibitory events consistent with GABAb duration suggests interventions for treatment of dystonia.
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