Head motion during MRI acquisition reduces gray matter volume and thickness estimates.
Head motion during MRI acquisition reduces gray matter volume and thickness estimates.
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DOI：
10.1016/j.neuroimage.2014.12.006
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发表时间：
2015-02-15
期刊：
影响因子：
5.7
通讯作者：
Fischl B
中科院分区：
文献类型：
--
作者：
Reuter M;Tisdall MD;Qureshi A;Buckner RL;van der Kouwe AJW;Fischl B
来自磁共振成像(MRI)数据的成像生物标记物被用来量化正常发育、疾病和疾病修饰疗法的效果。然而，图像采集过程中的运动会引入图像伪影，进而影响派生的标记。系统效应可能是有问题的，因为感兴趣的因素，如年龄、疾病和治疗，往往与扫描仪中的结构变化和头部运动量相关，混淆了区分生物学和伪像的能力。在这里，我们使用几个流行的图像分析软件(freesurfer 5.3、VBM8 SPM和FSL Siena 5.0.7)来评估图像采集过程中头部运动对人脑结构的形态测量估计的影响。12名健康志愿者在进行不同运动任务时收集了重复的T1加权磁共振成像，包括两次静止扫描。我们发现，大脑皮质灰质的体积和厚度估计因头部运动而产生偏差，受试者运动的平均表观体积损失约为0.7%/mm/min。不同地区的影响不同，在排除未通过严格质量检查的扫描后，影响仍然很大。鉴于这些结果，对运动障碍或其他运动倾向增加的情况的形态测量效应的解释可能需要重新审视：当不控制头部运动时，影响可能被高估。此外，使用催眠药、镇静剂、镇静剂或神经肌肉阻滞剂进行的药物研究可能只因为它们影响的运动与疾病或治疗过程的真实效果不同，就可能包含减少萎缩或大脑生长的虚假“效果”。
Imaging biomarkers derived from magnetic resonance imaging (MRI) data are used to quantify normal development, disease, and the effects of disease-modifying therapies. However, motion during image acquisition introduces image artifacts that, in turn, affect derived markers. A systematic effect can be problematic since factors of interest like age, disease, and treatment are often correlated with both a structural change and the amount of head motion in the scanner, confounding the ability to distinguish biology from artifact. Here we evaluate the effect of head motion during image acquisition on morphometric estimates of structures in the human brain using several popular image analysis software packages (FreeSurfer 5.3, VBM8 SPM, and FSL Siena 5.0.7). Within-session repeated T1-weighted MRIs were collected on 12 healthy volunteers while performing different motion tasks, including two still scans. We show that volume and thickness estimates of the cortical gray matter are biased by head motion with an average apparent volume loss of roughly 0.7%/mm/min of subject motion. Effects vary across regions and remain significant after excluding scans that fail a rigorous quality check. In view of these results, the interpretation of reported morphometric effects of movement disorders or other conditions with increased motion tendency may need to be revisited: effects may be overestimated when not controlling for head motion. Furthermore, drug studies with hypnotic, sedative, tranquillizing, or neuromuscular-blocking substances may contain spurious “effects” of reduced atrophy or brain growth simply because they affect motion distinct from true effects of the disease or therapeutic process.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
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