Age-dependent changes in cocaine sensitivity across early ontogeny in male and female rats: possible role of dorsal striatal D2(High) receptors.
Age-dependent changes in cocaine sensitivity across early ontogeny in male and female rats: possible role of dorsal striatal D2(High) receptors.
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DOI：
10.1007/s00213-014-3860-3
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发表时间：
2015-07
影响因子：
3.4
通讯作者：
Crawford, Cynthia A.
中科院分区：
文献类型：
--
作者：
McDougall, Sanders A.;Eaton, Shannon E.;Mohd-Yusof, Alena;Crawford, Cynthia A.
对急性精神兴奋剂的反应因个体发育而异。本研究的目的是确定D2High受体的年龄依赖性变化是否可能是断奶前、青春期和成年大鼠可卡因敏感性的个体发生原因。[3H]-多潘立酮/多巴胺竞争法测定雄性和雌性断奶前[产后（PD） 5、10、15和20]、青春期（PD 40）和成年大鼠（PD 80） d2 - high受体比例的个体发生变化。在行为实验中，在PD 20、PD 40和PD 80上评估对可卡因（2.5、5、10或20 mg/kg）的反应性60分钟。在测试前两天，雄性和雌性大鼠对仪器习以为常。行进距离数据显示为未转换的数据和生理盐水对照的百分比。雄性和雌性断奶前大鼠（PD 5-PD 20）的背纹状体d2 - high受体比例明显高于青春期或成年大鼠。同样，断奶前的大鼠（PD 20）对可卡因的行为影响比两个年龄较大的组更敏感。青少年大鼠和成年大鼠的反应方式大致相似，然而，对未转化的运动活动数据的分析表明，与成年大鼠相比，青少年大鼠对2.5和20 mg/kg可卡因的反应较低。本研究的数据与d2高受体的个体发生变化是导致精神兴奋剂敏感性年龄依赖性差异的假设是一致的。
Responsiveness to acute psychostimulant administration varies across ontogeny. The purpose of the present study was to determine if age-dependent changes in D2High receptors may be responsible for the ontogeny of cocaine sensitivity in preweanling, adolescent, and adult rats. [3H]-Domperidone/dopamine competition assays were used to determine ontogenetic changes in the proportion of D2High receptors in male and female preweanling [postnatal day (PD) 5, 10, 15, and 20], adolescent (PD 40), and adult rats (PD 80). In the behavioral experiment, responsiveness to cocaine (2.5, 5, 10, or 20 mg/kg) was assessed on PD 20, PD 40, and PD 80 for 60 min. Male and female rats were habituated to the apparatus on the two days prior to testing. Distance traveled data were presented both untransformed and as percent of saline controls. Male and female preweanling rats (PD 5–PD 20) had a significantly greater percentage of dorsal striatal D2High receptors than adolescent or adult rats. Likewise, preweanling rats (PD 20) were more sensitive to the behavioral effects of cocaine than the two older age groups. Adolescent and adult rats responded in a generally similar manner, however analysis of the untransformed locomotor activity data suggested that adolescent rats were hyporesponsive to 2.5 and 20 mg/kg cocaine when compared to adults. Data from the present study are consistent with the hypothesis that ontogenetic changes in D2High receptors are responsible for age-dependent differences in psychostimulant sensitivity.
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DOI：
10.1016/s0165-3806(98)00116-3
发表时间：
1998-11-01
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Bolanos, CA;Glatt, SJ;Jackson, D
通讯作者：
Jackson, D
影响因子：
4.7
作者：
Adriani, W;Laviola, G
通讯作者：
Laviola, G
影响因子：
3.4
作者：
Caster, JM;Walker, QD;Kuhn, CM
通讯作者：
Kuhn, CM
影响因子：
4.1
作者：
Brown, Russell W.;Hughes, Benjamin A.;Pond, Brooks B.
通讯作者：
Pond, Brooks B.
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL