Growth plate formation and development in alligator and mouse metapodials: evolutionary and functional implications.
Growth plate formation and development in alligator and mouse metapodials: evolutionary and functional implications.
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鳄鱼和小鼠后足生长板的形成和发育：进化和功能的影响。
DOI：
10.1002/jez.b.21148
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Lovejoy,COwen
中科院分区：
文献类型：
--
作者：
Reno,PhilipL;HortonJr,WalterE;Elsey,RuthM;Lovejoy,COwen
Mammalian metapodials (metacarpals and metatarsals), unlike most long bones, form a single growth plate, and undergo longitudinal growth at only one end. The growth dynamics of non‐mammalian tetrapod metapodials have not been systematically examined in order to determine if unidirectional growth is unique to mammals. Here we compare murine metapodial ossification in growth stages that parallel those of embryonic, juvenile and subadult American alligators (Alligator mississippiensis). Safranin O staining was used for qualitative histology, and chondrocyte differentiation and proliferation were assessed via immunohistochemistry for type X collagen and proliferative cell nuclear antigen (PCNA). We establish that growth plates form at both ends of alligator metapodials and are maintained in the subadult. PCNA results show that alligators and mice share common patterns of chondrocyte proliferation during growth plate formation. In addition, while alligators and mice differ initially in the degree of organization and pace of chondrocyte differentiation, these parameters are largely similar in established growth plates. However, the replacement of cartilage by bone is highly irregular throughout growth in the alligator, in contrast to the more uniform process in the mouse. These results indicate that while alligators and mammals share common mechanisms of chondrocyte regulation, they differ substantially in their processes of ossification. Phylogenetic analysis indicates that the direct ossification of one epiphysis and reliance on a single growth plate is a derived character (synapomorphy) in therian mammals and likely indicates an adaptation for erect quadrupedal gait.J. Exp. Zool. (Mol. Dev. Evol.) 308B:283–296, 2007. © 2007 Wiley‐Liss, Inc.
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DOI：
10.3109/10799898809048978
发表时间：
1988-01-01
期刊：
JOURNAL OF RECEPTOR RESEARCH
影响因子：
--
作者：
HOYER, D
通讯作者：
HOYER, D
通过放射自显影对小鼠中枢神经系统中的神经元 5-HT3 受体进行定位。
影响因子：
5
作者：
C. Waeber;K. Dixon;D. Hoyer;J. Palacios
通讯作者：
J. Palacios
新型镇痛药盐酸奈福泮对映体拆分：液相色谱和圆二色光谱研究
DOI：
--
发表时间：
1988
期刊：
The Journal of pharmacy and pharmacology
影响因子：
--
作者：
R. Isaksson;J. Sandström;Michal Eliaz;Zehorith Israely;I. Agranat
通讯作者：
I. Agranat
5-HT3受体的药理学和功能
影响因子：
15.9
作者：
B. Richardson;G. Engel
通讯作者：
G. Engel
BRL 43694（格拉司琼）具有选择性和功能性 5-羟色胺 3 受体拮抗作用。
影响因子：
5
作者：
G. Sanger;D. Nelson
通讯作者：
D. Nelson