Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery.
Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery.
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光学成像技术：识别手术后库欣病缓解情况的有用工具。
DOI：
10.1055/a-0801-8917
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Mazzuchi,T
中科院分区：
文献类型：
--
作者：
Afshari,Ali;Keil,Margaret;Lyssikatos,Charalampos;Belyavskaya,Elena;Valdés,Nuria;Chowdhry,FatimaA;Parsa,Kian;Ardeshirpour,Yasaman;Pursley,Randall;Khare,Siddharth;Kainerstorfer,JanaM;Chittiboina,Prashant;Lodish,MayaB;Mazzuchi,T
我们最近报道了使用光学成像技术来量化内源性库欣综合征（CS）的面部过多。在本研究中，我们研究了更大的库欣病 (CD) 患者队列，并检查了水含量分数和血容量分数作为生物光学标记，以确定该方法作为 CS 手术后持久缓解预测指标的有效性。我们对 49 名库欣病 (CD) 患者进行经蝶手术 (TSS) 前后进行了成像； 22 名患者在术后 3-6 个月接受观察，13 名患者在术后 12 个月接受治疗。对于所有患者，我们使用多光谱成像 (MSI) 来评估血液动力学分布以及面部特定区域的含水量。我们发现，根据生化指标测定，40 名患者中有 37 名的测试面部区域在手术治疗后与手术前相比有所下降（p<0.001）。所有随访长达 12 个月的患者均表现出与术前值相比相同的下降，并且他们仍处于 CD 缓解期。我们的结论是，MSI 可用于评估 CD 的缓解，至少在术后初期和术后一年内如此。该技术的使用可以补充生化和其他测试，以评估 CD 患者可用的各种治疗方式。
We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as blood volume fraction as bio-optic markers for determining the efficacy of this methodology as a predictor of lasting remission after surgery for CS. We imaged 49 patients before and after transsphenoidal surgery (TSS) for Cushing disease (CD); 22 patients were also seen at 3–6 months, and 13 patients 12 months post-operatively. On all patients, we used multi-spectral imaging (MSI) to evaluate hemodynamic distributions as well as water content at a specific area of the face. We found a decrease in blood volume fraction after vs. before surgical treatment in the tested facial area in 37 of the 40 patients, as determined with biochemical markers (p<0.001). All patients that were followed up for up to 12 months showed the same decrease from preoperative values and they remained in remission from CD. We conclude that MSI can be used for the evaluation of remission from CD, at least in the immediate post-operative period and up to one year after surgery. The use of this technology can supplement biochemical and other testing for the evaluation of the various treatment modalities available for patients with CD.
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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作者：
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