24-hour-restraint stress induces long-term depressive-like phenotypes in mice.
24-hour-restraint stress induces long-term depressive-like phenotypes in mice.
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DOI：
10.1038/srep32935
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发表时间：
2016-09-09
影响因子：
4.6
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Chu X;Zhou Y;Hu Z;Lou J;Song W;Li J;Liang X;Chen C;Wang S;Yang B;Chen L;Zhang X;Song J;Dong Y;Chen S;He L;Xie Q;Chen X;Li W
在地震中被困在瓦砾中的幸存者中，精神障碍的风险越来越大，如急性应激障碍(ASD)、创伤后应激障碍(PTSD)和抑郁症。单一急性束缚应激的长期影响还没有被广泛研究过。在本研究中，我们让小鼠受到24小时的束缚以模拟诱捕事件，并观察了急性(束缚后2天)和长期(束缚后35天)的影响。令人惊讶的是，我们发现在束缚35天后，小鼠表现出抑郁样的行为，大脑中葡萄糖摄取减少，成年海马神经发生减少。基于微阵列的差异表达图谱表明，与抑郁和其他精神障碍相关的基因和通路在前额叶和海马区都有差异表达。此外，抗抑郁药氟西汀可逆转24小时束缚所致的抑郁样表型。这些发现表明，一个单一的严重应激事件可能会产生长期的抑郁样表型。此外，24小时束缚应激小鼠也可以用于情绪障碍的进一步研究。
There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subjected mice to 24-hour-restraint to simulate the trapping episode, and investigated the acute (2 days after the restraint) and long-term (35 days after the restraint) impacts. Surprisingly, we found that the mice displayed depression-like behaviors, decreased glucose uptake in brain and reduced adult hippocampal neurogenesis 35 days after the restraint. Differential expression profiling based on microarrays suggested that genes and pathways related to depression and other mental disorders were differentially expressed in both PFC and hippocampus. Furthermore, the depression-like phenotypes induced by 24-hour-restraint could be reversed by fluoxetine, a type of antidepressant drug. These findings demonstrated that a single severe stressful event could produce long-term depressive-like phenotypes. Moreover, the 24-hour-restraint stress mice could also be used for further studies on mood disorders.
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