Qualitative interview study exploring the perspectives of pregnant women on participating in controlled human infection research in the UK.
Qualitative interview study exploring the perspectives of pregnant women on participating in controlled human infection research in the UK.
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定性访谈研究，探讨孕妇对参与英国受控人类感染研究的观点。
DOI：
10.1136/bmjopen-2023-073992
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发表时间：
2023-12-27
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
孕妇历来被排除在干预性研究之外。虽然最近已作出努力，以提高他们的参与，仍然存在差异的证据基础，为治疗提供孕妇与非怀孕人口相比。孕妇参与研究的一个重大障碍是风险意识和这一人群对决策的理解不足。在考虑是否参加假设的干预性研究时，评估风险认知和对孕妇决策的影响。进行了半结构化访谈，并对参与者的答复进行了专题分析。12名孕妇从产前门诊入组。参与者对参与拟议的假设干预性研究一致持积极态度。风险认知受到胎儿的潜在风险以及他们以前的医疗保健和研究经验的影响。与会者发现，量化新研究干预措施风险的不确定性具有挑战性。他们被利他主义激励着参与研究，并发现侵入性较小的研究干预更容易接受。了解孕妇如何平衡干预性研究的风险和益处至关重要。这可能有助于临床医生和科学家更好地向孕妇传达风险，并解决孕妇在干预性研究中持续代表性不足的问题。
Pregnant women have been historically excluded from interventional research. While recent efforts have been made to improve their involvement, there remains a disparity in the evidence base for treatments available to pregnant women compared with the non-pregnant population. A significant barrier to the enrolment of pregnant women within research is risk perception and a poor understanding of decision-making in this population. Assess the risk perception and influences on decision-making in pregnant women, when considering whether to enrol in a hypothetical interventional research study. Semistructured interviews were undertaken, and thematic analysis was undertaken of participant responses. Twelve pregnant women were enrolled from an antenatal outpatient clinic. Participants were unanimously positive about enrolling in the proposed hypothetical interventional study. Risk perception was influenced by potential risks to their fetus and their previous experiences of healthcare and research. Participants found the uncertainty in quantifying risk for new research interventions challenging. They were motivated to enrol in research by altruism and found less invasive research interventions more tolerable. It is vital to understand how pregnant women balance the perceived risks and benefits of interventional research. This may help clinicians and scientists better communicate risk to pregnant women and address the ongoing under-representation of pregnant women in interventional research.
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影响因子：
2.8
作者：
Crozier, Sarah R.;Robinson, Sian M.;Inskip, Hazel M.
通讯作者：
Inskip, Hazel M.
影响因子：
16.2
作者：
Kim, Catherine;McEwen, Laura N.;Walker, Elizabeth A.
通讯作者：
Walker, Elizabeth A.
影响因子：
2.5
作者：
Li, Meng;Chapman, Gretchen B.
通讯作者：
Chapman, Gretchen B.
影响因子：
4.2
作者：
Carolan, Mary C.
通讯作者：
Carolan, Mary C.
DOI：
10.1002/ajmg.c.30313
发表时间：
2011-08-15
影响因子：
3.1
作者：
Adam, Margaret P.;Polifka, Janine E.;Friedman, J. M.
通讯作者：
Friedman, J. M.