Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling.
Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling.
复制标题
DOI：
10.1242/dev.025742
复制
发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Pleasure SJ
中科院分区：
文献类型：
--
作者：
Li G;Kataoka H;Coughlin SR;Pleasure SJ
齿状回发育的一个显著特征是神经前体从脑室区迁移到形成的齿状极，产生终身的神经源性颗粒下区（SGZ）。在这项研究中，我们证明，齿状祖细胞首先居住在一个以前未被识别的神经原区密切相关的软脑膜表面内衬的外边缘形成齿状线长达1周。该区域也作为齿状神经胶质支架最初形成的组织基质。神经前体从其瞬时位置的及时清除依赖于reelin，而这种瞬时干细胞龛的初始形成需要Cxcl 12-Cxcr 4信号传导。神经前体在颗粒下区的最终定居依赖于独立于Cxcl 12-Cxcr 4信号传导的百日咳毒素敏感途径。此外，遗传命运定位分析表明，软膜下前体有助于SGZ的形成。这些结果表明，在齿状回的神经前体的重新定位由多个途径调节的离散步骤。
One striking feature of dentate gyrus development, distinct from the other cortical structures, is the relocation of neural precursors from the ventricular zone to the forming dentate pole to produce a lifelong neurogenic subgranular zone (SGZ). In this study, we demonstrate that dentate progenitors first dwell for up to 1 week in a previously unrecognized neurogenic zone intimately associated with the pial meningeal surface lining the outer edge of the forming dentate. This zone also serves as the organizational matrix for the initial formation of the dentate glial scaffolding. Timely clearance of neural precursors from their transient location depends on reelin, whereas initial formation of this transient stem cell niche requires Cxcl12-Cxcr4 signaling. The final settlement of the neural precursors at the subgranular zone relies on a pertussis toxin-sensitive pathway independent of Cxcl12-Cxcr4 signaling. Furthermore, genetic fate-mapping analysis suggests that subpial precursors contribute to the SGZ formation. These results demonstrate that the relocation of neural precursors in the dentate gyrus consists of discrete steps regulated by multiple pathways.
登录
查看更多内容
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
影响因子：
7.5
作者：
Merkle, Florian T.;Alvarez-Buylla, Arturo
通讯作者：
Alvarez-Buylla, Arturo
影响因子：
10.5
作者：
Arnold, Sebastian J.;Huang, Guo-Jen;Groszer, Matthias
通讯作者：
Groszer, Matthias
DOI：
10.1073/pnas.202035899
发表时间：
2002-10-01
影响因子：
11.1
作者：
Förster, E;Tielsch, A;Frotscher, M
通讯作者：
Frotscher, M
影响因子：
25
作者：
Lai, K;Kaspar, BK;Schaffer, DV
通讯作者：
Schaffer, DV