b -Catenin Expression Pattern in Stage I and II Ovarian Carcinomas Relationship with b -Catenin Gene Mutations, Clinicopathological Features, and Clinical Outcome
b -Catenin Expression Pattern in Stage I and II Ovarian Carcinomas Relationship with b -Catenin Gene Mutations, Clinicopathological Features, and Clinical Outcome
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I 期和 II 期卵巢癌中的 b-Catenin 表达模式与 b-Catenin 基因突变、临床病理特征和临床结果的关系
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
A. Armas
中科院分区：
文献类型：
--
作者：
C. Gamallo;J. Palacios;G. Moreno;J. Mora;A. Suárez;A. Armas
β-连环蛋白的免疫组织化学表达模式与 69 例 I 期和 II 期卵巢癌中的 β-连环蛋白基因突变、临床病理特征和疾病结果相关。在 11 个肿瘤 (16%) 中，除细胞质和膜外，b-连环蛋白表达还局限于细胞核：9 个子宫内膜样癌具有广泛的核表达，2 个浆液性癌具有局灶性核表达。其余 58 个癌 (84%) 仅具有膜性 β-连环蛋白表达。除1例核b-连环蛋白表达的子宫内膜样癌外，所有病例均具有相当大的鳞状化生，其中5例具有大面积的低度恶性潜能的子宫内膜样肿瘤。此外，在与子宫内膜样癌相邻的子宫内膜异位腺体的非典型上皮细胞中观察到β-连环蛋白核表达。对 25 个肿瘤和相应的正常组织进行了测序：所有 13 个子宫内膜样肿瘤以及 12 个其他组织学类型的癌（四种浆液性、两种透明细胞、两种粘液性和两种混合性）。在7个核表达b-catenin的子宫内膜样癌中，b-catenin基因外显子3的GSK-3b磷酸化序列存在致癌突变。三种突变影响密码子 32（D32G、D32Y 和 D32Y），一种
The immunohistochemical expression pattern of b -catenin has been correlated with b -catenin gene mutations, clinicopathological features, and disease outcome in 69 stage I and II ovarian carcinomas. b -Catenin expression was localized in the nuclei, in addition to the cytoplasm and membrane, in 11 tumors (16%): nine endometrioid carcinomas with widespread nuclear expression and two serous carcinomas with focal nuclear expression. The remaining 58 carcinomas (84%) only had membranous b -cate-nin expression. All but one of the endometrioid carcinomas with nuclear b -catenin expression had con-siderable squamous metaplasia, and five of these cases had large areas of endometrioid tumor of low malignant potential. In addition, b -catenin nuclear expression was observed in atypical epithelial cells in endometriotic glands adjacent to an endometrioid carcinoma. Sequencing was performed on 25 tumors and corresponding normal tissue: all 13 endometrioid tumors as well as 12 carcinomas of other histological types (four serous, two clear cell, two mucinous, and two mixed). There were oncogenic mutations in the phosphorylation sequence for GSK-3 b in exon 3 of the b -catenin gene in seven endometrioid carcinomas with b -catenin nuclear expression. Three mutations affected codon 32 (D32G, D32Y, and D32Y), one
影响因子：
11.2
作者：
R. Iozzo;I. Eichstetter;K. Danielson
通讯作者：
R. Iozzo;I. Eichstetter;K. Danielson
影响因子：
2.7
作者：
PEIFER, M;PAI, LM;CASEY, M
通讯作者：
CASEY, M