Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference.
Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference.
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DOI：
10.1186/1472-6823-14-72
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发表时间：
2014-08-26
影响因子：
2.7
通讯作者：
Ferdinandy P
中科院分区：
文献类型：
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作者：
Sárközy M;Fekete V;Szűcs G;Török S;Szűcs C;Bárkányi J;Varga ZV;Földesi I;Csonka C;Kónya C;Csont T;Ferdinandy P
虽然多种维生素产品被广泛用作维持健康的膳食补充剂，或作为治疗某些疾病的特殊医疗食品，但这些产品对糖尿病（一种主要的心血管危险因素）的影响尚未进行研究。因此，我们在这里研究了不同的矿物质、维生素和微量元素（MVT）的制备是否会影响实验性糖尿病的严重程度。用100 mg/kg链脲佐菌素或其载药诱导2日龄新生Wistar大鼠糖尿病。第4周，大鼠分别饲喂MVT制剂或载药8周。在第4周、第8周和第12周进行糖尿病的诊断参数，即空腹血糖和口服葡萄糖耐量试验。第12周测定血清胰岛素和血糖化血红蛋白。经链脲佐菌素治疗的大鼠，不论性别，在第4周均发现糖耐量受损。在男性中，与非糖尿病组相比，车辆治疗的糖尿病组在第12周的空腹血糖和HbA1c显著升高，葡萄糖耐量和血清胰岛素降低。MVT治疗对雄性大鼠糖尿病的各项诊断指标均有显著改善。在女性中，链脲佐菌素治疗导致了较轻的糖尿病前期样表型，因为在研究结束时，与非糖尿病组相比，药物治疗的糖尿病组只有葡萄糖耐量和HbA1c发生了改变。MVT治疗未能改善雌性链脲佐菌素治疗大鼠糖尿病的诊断参数。这是第一次证明MVT显著减缓慢性实验性糖尿病雄性大鼠的糖尿病进展。此外，我们已经证实雌性对stz诱导的糖尿病不太敏感，MVT制剂对糖尿病前期状态没有保护作用。这可能表明糖尿病的发病机制存在性别差异。
Although multivitamin products are widely used as dietary supplements to maintain health or as special medical food in certain diseases, the effects of these products were not investigated in diabetes mellitus, a major cardiovascular risk factor. Therefore, here we investigated if a preparation of different minerals, vitamins, and trace elements (MVT) for human use affects the severity of experimental diabetes. Two days old neonatal Wistar rats from both genders were injected with 100 mg/kg of streptozotocin or its vehicle to induce diabetes. At week 4, rats were fed with an MVT preparation or vehicle for 8 weeks. Well established diagnostic parameters of diabetes, i.e. fasting blood glucose and oral glucose tolerance test were performed at week 4, 8 and 12. Moreover, serum insulin and blood HbA1c were measured at week 12. An impaired glucose tolerance has been found in streptozotocin-treated rats in both genders at week 4. In males, fasting blood glucose and HbA1c were significantly increased and glucose tolerance and serum insulin was decreased at week 12 in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. All of the diagnostic parameters of diabetes were significantly improved by MVT treatment in male rats. In females, streptozotocin treatment resulted in a less severe prediabetic-like phenotype as only glucose tolerance and HbA1c were altered by the end of the study in the vehicle-treated diabetic group as compared to the vehicle-treated non-diabetic group. MVT treatment failed to improve the diagnostic parameters of diabetes in female streptozotocin-treated rats. This is the first demonstration that MVT significantly attenuates the progression of diabetes in male rats with chronic experimental diabetes. Moreover, we have confirmed that females are less sensitive to STZ-induced diabetes and MVT preparation did not show protection against prediabetic state. This may suggest a gender difference in the pathogenesis of diabetes.
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影响因子：
9.8
作者：
BONNERWEIR, S;TRENT, DF;WEIR, GC
通讯作者：
WEIR, GC
影响因子：
5
作者：
Li, Kuanrong;Kaaks, Rudolf;Rohrmann, Sabine
通讯作者：
Rohrmann, Sabine
影响因子：
16.2
作者：
Farvid, MS;Jalali, M;Hosseini, M
通讯作者：
Hosseini, M
影响因子：
4.2
作者：
Bailey, Regan L.;Gahche, Jaime J.;Picciano, Mary Frances
通讯作者：
Picciano, Mary Frances
DOI：
10.1046/j.1467-789x.2000.00013.x
发表时间：
2000-10-01
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Astrup, A;Finer, N
通讯作者：
Finer, N