High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review.
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review.
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DOI：
10.3390/cells10113164
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发表时间：
2021-11-14
期刊：
影响因子：
6
通讯作者：
Mądry E
中科院分区：
文献类型：
--
作者：
Malesza IJ;Malesza M;Walkowiak J;Mussin N;Walkowiak D;Aringazina R;Bartkowiak-Wieczorek J;Mądry E
肠道微生物群负责从食物中回收能量，为宿主提供维生素，并提供针对外源病原体的屏障功能。此外，它还参与维持肠上皮屏障的完整性，这对于肠道免疫系统的功能成熟至关重要。西方饮食（WD）是一种高脂肪消耗的不健康饮食，其大致特征是暴饮暴食、频繁吃零食和长时间的餐后状态。术语 WD 是众所周知的并且可以直观地理解。然而，营养比例的严格数字表达并没有精确定义。根据美国 1908 年至 1989 年的数据，来自脂肪的卡路里摄入量从 32% 增加到 45%。除了代谢方面（高胰岛素血症、胰岛素抵抗、血脂异常、交感神经系统和肾素-血管紧张素系统过度刺激以及氧化应激）外，过量脂肪消耗（高脂饮食——HFD）的后果还包括生态失调、肠道屏障功能障碍、肠道通透性增加以及有毒细菌代谢物渗漏到循环中。这些可以强烈促进低度全身炎症的发展。这篇叙述性综述强调了将 HFD 驱动的生态失调和 HFD 相关炎症联系起来的最重要的最新进展，介绍了这些现象的病理机制，并研究了促炎症状态和肠道微生物群变化之间可能的因果关系。
The gut microbiota is responsible for recovering energy from food, providing hosts with vitamins, and providing a barrier function against exogenous pathogens. In addition, it is involved in maintaining the integrity of the intestinal epithelial barrier, crucial for the functional maturation of the gut immune system. The Western diet (WD)—an unhealthy diet with high consumption of fats—can be broadly characterized by overeating, frequent snacking, and a prolonged postprandial state. The term WD is commonly known and intuitively understood. However, the strict digital expression of nutrient ratios is not precisely defined. Based on the US data for 1908–1989, the calory intake available from fats increased from 32% to 45%. Besides the metabolic aspects (hyperinsulinemia, insulin resistance, dyslipidemia, sympathetic nervous system and renin-angiotensin system overstimulation, and oxidative stress), the consequences of excessive fat consumption (high-fat diet—HFD) comprise dysbiosis, gut barrier dysfunction, increased intestinal permeability, and leakage of toxic bacterial metabolites into the circulation. These can strongly contribute to the development of low-grade systemic inflammation. This narrative review highlights the most important recent advances linking HFD-driven dysbiosis and HFD-related inflammation, presents the pathomechanisms for these phenomena, and examines the possible causative relationship between pro-inflammatory status and gut microbiota changes.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
DOI：
10.1186/1476-9255-9-48
发表时间：
2012-11-28
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Ahmad R;Al-Mass A;Atizado V;Al-Hubail A;Al-Ghimlas F;Al-Arouj M;Bennakhi A;Dermime S;Behbehani K
通讯作者：
Behbehani K
影响因子：
6.1
作者：
Bernstein, Carol;Holubec, Hana;Bhattacharyya, Achyut K.;Huy Nguyen;Payne, Claire M.;Zaitlin, Beryl;Bernstein, Harris
通讯作者：
Bernstein, Harris
DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
11.1
作者：
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
通讯作者：
Burcelin, Remy