Oscillatory brain dynamics supporting impaired Stroop task performance in schizophrenia-spectrum disorder
Oscillatory brain dynamics supporting impaired Stroop task performance in schizophrenia-spectrum disorder
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振荡脑动力学支持精神分裂症谱系障碍中斯特鲁普任务表现受损
DOI：
10.1016/j.schres.2018.08.026
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发表时间：
2018
影响因子：
4.5
通讯作者：
Rockstroh
中科院分区：
文献类型：
--
作者：
Kustermann;Popova;Miller;Rockstroh
Stroop色词干扰任务对颜色不一致的反应比对一致的反应慢，常用于研究精神分裂症谱系障碍的抑制控制和功能障碍的神经机制。增强Stroop效应的不一致发现限制了对精神分裂症相关功能障碍机制的识别。本研究旨在通过分析40名患者（SZ）和27名健康对照参与者（HC）的行为表现和4-7 Hz（θ）和10-30 Hz（α/β）EEG振荡，通过区分精神分裂症谱系障碍Stroop任务期间的干扰检测和反应准备，来促进对正常和受损神经振荡动力学的理解。SZ的反应更慢，在INC试验期间表现出更少的背侧前扣带（dACC）θ增强，在INC试验期间表现出更少的dACC-感觉运动皮层连接（θ相位同步）增强，在INC试验期间表现出更多的α/β抑制，尽管抑制的增强较少，并且比HC更慢的反应后α/β反弹。反应时间分布显示较大的组和Stroop效应在25%的试验最慢的反应。患者中的POOX-theta相位相干性表明与干扰处理（dACC）和反应准备（感觉运动皮层）相关的区域之间的通信受损。结果表明，一个失败的级联反应，其中受损的行为Stroop效应至少部分地由功能失调的干扰处理（θ功率增加较少）驱动，促使功能失调的运动反应准备（α/β功率抑制较少）。不一致的Stroop效应在过去的研究精神分裂症可能会导致不同的任务参数抽样不同程度的Stroop任务难度。
The Stroop color-word interference task, prompting slower response to color-incongruent than to congruent items, is often used to study neural mechanisms of inhibitory control and dysfunction in schizophrenia-spectrum disorders. Inconsistent findings of an augmented Stroop effect limit identification of relevant dysfunctional mechanism(s) in schizophrenia. The present study sought to advance understanding of normal and impaired neural oscillatory dynamics by distinguishing interference detection and response preparation during the Stroop task in schizophrenia-spectrum disorders via analysis of behavioral performance and 4–7 Hz (theta) and 10–30 Hz (alpha/beta) EEG oscillations in 40 patients (SZ) and 27 healthy comparison participants (HC). SZ responded more slowly and showed less dorsal anterior cingulate (dACC) theta enhancement during INC trials, less enhancement of dACC-sensorimotor cortex connectivity (theta phase synchrony) during INC trials, more alpha/beta suppression though less enhancement of that suppression during INC trials, and slower post-response alpha/beta rebound than did HC. Reaction time distributions showed larger group and Stroop effects during the 25% of trials with the slowest responses. Poorer theta phase coherence in patients indicates impaired communication between regions associated with interference processing (dACC) and response preparation (sensorimotor cortex). Results suggest a failure cascade in which compromised behavioral Stroop effects are driven at least in part by dysfunctional interference processing (less theta power increase) prompting dysfunctional motor response preparation (less alpha/beta power suppression). Inconsistent Stroop effects in past studies of schizophrenia may result from differing task parameters sampling different degrees of Stroop task difficulty.
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影响因子：
6.6
作者：
Carter, Cameron S.;Minzenberg, Michael;Macdonald, Angus, III
通讯作者：
Macdonald, Angus, III
DOI：
10.1017/s1355617713000532
发表时间：
2013-08
影响因子：
2.6
作者：
Woodward, Neil D.;Duffy, Brittney;Karbasforoushan, Haleh
通讯作者：
Karbasforoushan, Haleh
影响因子：
--
作者：
Minzenberg, Michael J.;Laird, Angela R.;Thelen, Sarah;Carter, Cameron S.;Glahn, David C.
通讯作者：
Glahn, David C.
256 注意力分散的“好处”：精神分裂症斯特鲁普促进作用增强的机制
影响因子：
4.5
作者：
D. Barch;C. Carter;J. Cohen;P. C. Hachten
通讯作者：
P. C. Hachten
影响因子：
2.6
作者：
Jingting Zhao;Wei-Kuang Liang;C. Juan;Lin Wang;Suiping Wang;Zude Zhu
通讯作者：
Jingting Zhao;Wei-Kuang Liang;C. Juan;Lin Wang;Suiping Wang;Zude Zhu