Assessment of mechanical properties of articular cartilage with quantitative three-dimensional ultrashort echo time (UTE) cones magnetic resonance imaging.
Assessment of mechanical properties of articular cartilage with quantitative three-dimensional ultrashort echo time (UTE) cones magnetic resonance imaging.
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DOI：
10.1016/j.jbiomech.2020.110085
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发表时间：
2020-12-02
影响因子：
2.4
通讯作者：
Du J
中科院分区：
文献类型：
--
作者：
Namiranian B;Jerban S;Ma Y;Dorthe EW;Masoud-Afsahi A;Wong J;Wei Z;Chen Y;D'Lima D;Chang EY;Du J
传统的磁共振成像（MRI）由于其横向弛豫时间（T2）短，无法检测到来自深层软骨的信号。此外，一些定量MRI技术明显受到魔角效应的影响。超短回波时间（UTE） MRI与磁化转移（UTE- mt）和绝热T1ρ (UTE- adiabt1 ρ)成像的组合允许对关节软骨的所有区域进行魔角不敏感评估。本研究的目的是探讨定量三维UTE MRI生物标志物与人胫股软骨标本力学性能之间的相关性。从3名男性和4名女性供体（64±18岁）共采集了40份人胫股软骨标本。软骨样本在临床3T扫描仪上使用一系列定量3D UTE锥体T2* (UTE-T2*)、T1 （UTE-T1）、UTE- adiabt1 ρ和UTE- mt序列在标准膝关节圈中进行扫描。通过一系列MT功率和频率偏移获取UTE-MT数据，通过建模计算磁化传递比（MTR），以及大分子分数（MMF）和大分子T2 （T2mm）。采用压痕法测定软骨刚度和Hayes弹性模量。研究了三维UTE锥在浅层、深层和全局感兴趣区域（roi）的MRI测量与机械性能的相关性。软骨力学性能显示与软骨浅层的UTE测量有最高的相关性。浅层roi中的AdiabT1ρ、MTR和MMF与Hayes弹性模量呈显著相关（p<0.05， R分别为- 0.54、0.49和0.66）。这些UTE在全球roi中的测量值与Hayes弹性模量的相关性（p<0.05， R分别= - 0.37,0.52和0.60）显着（尽管略低）。其他UTE MRI测量值（T2*、T1和T2mm）与力学性能之间的相关性无统计学意义。3D UTE-AdiabT1ρ和UTE-MT序列被强调为无创软骨力学性能评估的有希望的替代品。来自UTE-MT模型的MMF与软骨力学的相关性最高。
Conventional magnetic resonance imaging (MRI) is not capable of detecting signal from the deep cartilage due to its short transverse relaxation time (T2). Moreover, several quantitative MRI techniques are significantly influenced by the magic angle effect. The combinations of ultrashort echo time (UTE) MRI with magnetization transfer (UTE-MT) and Adiabatic T1ρ (UTE-AdiabT1ρ) imaging allow magic angle-insensitive assessments of all regions of articular cartilage. The purpose of this study was to investigate the correlations between quantitative three-dimensional UTE MRI biomarkers and mechanical properties of human tibiofemoral cartilage specimens. In total, 40 human tibiofemoral cartilage specimens were harvested from three male and four female donors (64±18 years old). Cartilage samples were scanned using a series of quantitative 3D UTE Cones T2* (UTE-T2*), T1 (UTE-T1), UTE-AdiabT1ρ, and UTE-MT sequences in a standard knee coil on a clinical 3T scanner. UTE-MT data were acquired with a series of MT powers and frequency offsets to calculate magnetization transfer ratio (MTR), as well as macromolecular fraction (MMF) and macromolecular T2 (T2mm) through modeling. Cartilage stiffness and Hayes elastic modulus were measured using indentation tests. Correlations of 3D UTE Cones MRI measurements in the superficial layer, deep layer, and global regions of interest (ROIs) with mechanical properties were investigated. Cartilage mechanical properties demonstrated highest correlations with UTE measures of the superficial layer of cartilage. AdiabT1ρ, MTR, and MMF in superficial layer ROIs showed significant correlations with Hayes elastic modulus (p<0.05, R=−0.54, 0.49, and 0.66, respectively). These UTE measures in global ROIs showed significant, though slightly lower, correlations with Hayes elastic modulus (p<0.05, R=−0.37, 0.52, and 0.60, respectively). Correlations between other UTE MRI measurements (T2*, T1, and T2mm) and mechanical properties were non-significant. The 3D UTE-AdiabT1ρ and UTE-MT sequences were highlighted as promising surrogates for non-invasive assessment of cartilage mechanical properties. MMF from UTE-MT modeling showed the highest correlations with cartilage mechanics.
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