Peripheral Dendritic Cells and CD4+CD25+Foxp3+ Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage.
Peripheral Dendritic Cells and CD4+CD25+Foxp3+ Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage.
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DOI：
10.1371/journal.pone.0124747
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kwaśniewska A
中科院分区：
文献类型：
--
作者：
Kwiatek M;Gęca T;Krzyżanowski A;Malec A;Kwaśniewska A
怀孕的发展是可能的，因为母亲体内免疫反应的启动导致免疫耐受。流产可能是由于母体对位于滋养层和胎儿细胞表面的父方同种异体抗原的免疫反应受损所致。该研究的目的是比较正常妊娠的前三个月和复发性流产妇女的循环树突状细胞（DC）和CD 4 + CD 25 + Foxp 3+调节性T细胞（Tregs）的数量，并试图确定这些细胞之间的关系及其在人类生殖失败中可能发挥的作用。该研究在一组33名复发性流产的早期妊娠妇女和一组20名正常妊娠早期妊娠的健康孕妇中进行。在从外周血分离的单核细胞中，通过流式细胞术评估DC和Treg的群体。髓系DC和淋巴系DC的百分比在研究组和对照组之间无显著差异。高龄产妇和肥胖显著减少了循环髓样和淋巴样DC的池（R=-0.39，p =0.02）。在流产中，与正常妊娠相比，循环Treg的百分比显著较低（p=0.003）。在分析的因素中，Tregs的百分比是与妊娠丢失相关的最敏感和最特异的参数。循环Treg群体的减少表明妊娠并发流产中的免疫调节机制紊乱。
The development of pregnancy is possible due to initiation of immune response in the body of the mother resulting in immune tolerance. Miscarriage may be caused by the impaired maternal immune response to paternal alloantigens located on the surface of trophoblast and fetal cells. The aim of the study was to compare the population of circulating dendritic cells (DCs) and CD4+CD25+Foxp3+ regulatory T cells (TREGs) in the first trimester of a normal pregnancy and in women with recurrent miscarriage and an attempt to determine the relationship between these cells and the role they may play in human reproductive failures. The study was conducted in a group of 33 first trimester pregnant women with recurrent miscarriage and in a group of 20 healthy pregnant women in the first trimester of normal pregnancy. Among mononuclear cells isolated from peripheral blood, the populations of DCs and TREGs were assessed by flow cytometry. The percentage of myeloid DCs and lymphoid DCs showed no significant difference between study and control group. Older maternal age and obesity significantly reduced the pool of circulating myeloid and lymphoid DCs (R=-0.39, p=0.02). In miscarriages the percentage of circulating TREGs was significantly lower compared to normal pregnancies (p=0.003). Among the analysed factors the percentage of TREGs was the most sensitive and the most specific parameter which correlated with the pregnancy loss. The reduction in the population of circulating TREGs suggests immunoregulatory mechanisms disorder in a pregnancy complicated by miscarriage.
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影响因子：
4.4
作者：
Panda, Alexander;Qian, Feng;Shaw, Albert C.
通讯作者：
Shaw, Albert C.
影响因子：
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DOI：
10.1097/01.gco.0000194112.86051.26
发表时间：
2005-12-01
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