Sleep and circadian contributions to adolescent alcohol use disorder.

Sleep and circadian contributions to adolescent alcohol use disorder.
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DOI:
10.1016/j.alcohol.2014.06.010
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发表时间:
2015-06
期刊:
影响因子:
2.3
通讯作者:
Clark, Duncan B.
Clark, Duncan B.
中科院分区:
医学4区
文献类型:
--
作者:
Hasler, Brant P.;Soehner, Adriane M.;Clark, Duncan B.

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青春期是一个在睡眠、昼夜节律、大脑功能和酒精使用方面发生显著变化的时期。从青春期开始,青少年的内源性昼夜节律和偏好的睡眠时间发生变化,往往导致与中等教育所强加的时间表不匹配。这种不匹配会导致昼夜节律失调和睡眠不足,这与青少年和成人的情绪失调、药物和酒精使用增加以及其他冒险行为有关。与睡眠中的发育变化平行,青少年的大脑正在经历结构和功能的变化,这些变化有助于追求和处理奖励。这些奖励处理的发展变化可能有助于在青春期开始使用酒精。大量证据表明,睡眠和昼夜节律调节奖赏功能,这表明青少年睡眠和昼夜节律紊乱可能有助于改变奖赏功能,反过来,酒精参与。在这篇综述中,我们总结了相关的证据,并提出这些平行的发展变化的睡眠,昼夜节律和神经处理的奖励相互作用,以增加酒精使用障碍(AUD)的风险。
Adolescence is a time of marked changes across sleep, circadian rhythms, brain function, and alcohol use. Starting at puberty, adolescents’ endogenous circadian rhythms and preferred sleep times shift later, often leading to a mismatch with the schedules imposed by secondary education. This mismatch induces circadian misalignment and sleep loss, which have been associated with affect dysregulation, increased drug and alcohol use, and other risk-taking behaviors in adolescents and adults. In parallel to developmental changes in sleep, adolescent brains are undergoing structural and functional changes in the circuits subserving the pursuit and processing of rewards. These developmental changes in reward processing likely contribute to the initiation of alcohol use during adolescence. Abundant evidence indicates that sleep and circadian rhythms modulate reward function, suggesting that adolescent sleep and circadian disturbance may contribute to altered reward function, and in turn, alcohol involvement. In this review, we summarize the relevant evidence and propose that these parallel developmental changes in sleep, circadian rhythms, and neural processing of reward interact to increase risk for alcohol use disorder (AUD).
酒精依赖患者失眠的认知行为疗法:一项随机对照试点试验。
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