Genetic and epigenetic heterogeneity and the impact on cancer relapse.
Genetic and epigenetic heterogeneity and the impact on cancer relapse.
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DOI：
10.1016/j.exphem.2017.07.002
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发表时间：
2017-10
影响因子：
2.6
通讯作者：
Mason CE
中科院分区：
文献类型：
--
作者：
Hassan C;Afshinnekoo E;Li S;Wu S;Mason CE
Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy with an exceedingly poor prognosis, showing a 5-year overall survival rate of 40–45% in the young and a 5-year survival rate of below 10% in the elderly (>60y). Though a high percentage of patients enter complete remission following chemotherapeutic intervention, the majority of patients relapse within three years. Such stark prognostic outcomes highlight the need for additional clinical research, basic discovery, and molecular delineation of the etiologies and mechanisms behind responses to therapy that lead to relapse. Here we summarize recent discoveries in tumor heterogeneity at the genetic and epigenetic levels, and their independent molecular trajectories and dynamics in response to therapy. These new discoveries may have significant implications for understanding, monitoring, and treating leukemia and other cancers.
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影响因子：
30.8
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
影响因子：
82.9
作者：
Guryanova OA;Shank K;Spitzer B;Luciani L;Koche RP;Garrett-Bakelman FE;Ganzel C;Durham BH;Mohanty A;Hoermann G;Rivera SA;Chramiec AG;Pronier E;Bastian L;Keller MD;Tovbin D;Loizou E;Weinstein AR;Gonzalez AR;Lieu YK;Rowe JM;Pastore F;McKenney AS;Krivtsov AV;Sperr WR;Cross JR;Mason CE;Tallman MS;Arcila ME;Abdel-Wahab O;Armstrong SA;Kubicek S;Staber PB;Gönen M;Paietta EM;Melnick AM;Nimer SD;Mukherjee S;Levine RL
通讯作者：
Levine RL
影响因子：
82.9
作者：
Li S;Garrett-Bakelman FE;Chung SS;Sanders MA;Hricik T;Rapaport F;Patel J;Dillon R;Vijay P;Brown AL;Perl AE;Cannon J;Bullinger L;Luger S;Becker M;Lewis ID;To LB;Delwel R;Löwenberg B;Döhner H;Döhner K;Guzman ML;Hassane DC;Roboz GJ;Grimwade D;Valk PJ;D'Andrea RJ;Carroll M;Park CY;Neuberg D;Levine R;Melnick AM;Mason CE
通讯作者：
Mason CE
影响因子：
--
作者：
HOLMES, RI;KEATING, MJ;FREIREICH, EJ
通讯作者：
FREIREICH, EJ
影响因子：
6.5
作者：
PREISLER, HD;ANDERSON, K;HOLLAND, JF
通讯作者：
HOLLAND, JF