Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice.
Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice.
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幽门螺杆菌感染加重饮食诱导的胰岛素抵抗与小鼠肠道菌群的关系
DOI：
10.1016/j.ebiom.2016.09.010
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发表时间：
2016-10
期刊：
影响因子：
11.1
通讯作者：
Lu, Nonghua
中科院分区：
文献类型：
--
作者：
He, Cong;Yang, Zhen;Cheng, Dandan;Xie, Chuan;Zhu, Yin;Ge, Zhongming;Luo, Zhijun;Lu, Nonghua
新的证据表明，幽门螺杆菌感染与胰岛素抵抗（IR）有关，但其潜在机制仍不清楚。肠道菌群在胰岛素抵抗中的重要作用已被越来越多的报道，但尚未有研究探讨肠道菌群与H。pylori相关的IR。幽门螺杆菌感染小鼠模型，我们证明了H。pylori感染在早期显著加重高脂饮食（HFD）引起的代谢紊乱，其程度接近长期HFD的影响。有趣的是，我们观察到肠道微生物群的动态变化与H诱导的代谢表型变化一致。pylori和HFD。H.幽门螺杆菌，饮食和肠道微生物群，其失调宿主代谢稳态，以及H. pylori对糖耐量减低患者在饮食控制的基础上可能有益。H. pylori感染可加重高脂饮食诱导的C57 BL/6小鼠早期代谢紊乱。H.高脂饮食中的幽门螺杆菌感染诱导与代谢表型一致的肠道微生物群的动态改变。H.幽门螺杆菌是引起胃部疾病的最常见的人类细菌病原体之一。流行病学研究表明，其感染与胰岛素抵抗有关，但其机制尚不清楚。研究表明，H.幽门螺杆菌感染在早期阶段显著加重高脂饮食诱导的代谢紊乱，伴随着肠道微生物群的显著改变。此外，肠道菌群的变化与代谢表型一致，表明H。幽门、饮食和肠道菌群。因此，H. pylori对糖耐量减低患者在饮食控制的基础上可能有益。
Emerging evidence suggests that Helicobacter pylori infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and H. pylori-associated IR. Using H. pylori-infected mice model fed different diet structures, we demonstrated that H. pylori infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD. Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by H. pylori and HFD. There may be an interaction among H. pylori, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control. H. pylori infection aggravates high-fat diet induced metabolic disorders at the early stage in C57BL/6 mice. H. pylori infection in high-fat diet induces dynamic alterations of gut microbiota consistent with the metabolic phynotype. H. pylori is one of the most common human bacterial pathogens which causes gastric disorders. Epidemiological studies show that its infection is associated with insulin resistance although the mechanism is obscure. Our study demonstrates that H. pylori infection significantly aggravates high-fat diet induced metabolic disorders at the early stage, accompanied by dramatic alterations of gut microbiota. Moreover, the changes of gut microbiota are consistent with the metabolic phynotype, indicating an interaction among H. pylori, diet and gut microbiota. Thus, the treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.4
作者：
Goh KL;Chan WK;Shiota S;Yamaoka Y
通讯作者：
Yamaoka Y
影响因子：
3.7
作者：
Kim KA;Gu W;Lee IA;Joh EH;Kim DH
通讯作者：
Kim DH
影响因子：
16.2
作者：
Jeon CY;Haan MN;Cheng C;Clayton ER;Mayeda ER;Miller JW;Aiello AE
通讯作者：
Aiello AE
影响因子：
3.7
作者：
Knigge A;Klöting N;Schön MR;Dietrich A;Fasshauer M;Gärtner D;Lohmann T;Dreßler M;Stumvoll M;Kovacs P;Blüher M
通讯作者：
Blüher M