Helicobacter pylori infection is associated with an increased rate of diabetes.
Helicobacter pylori infection is associated with an increased rate of diabetes.
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DOI：
10.2337/dc11-1043
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发表时间：
2012-03
期刊：
影响因子：
16.2
通讯作者：
Aiello AE
中科院分区：
文献类型：
--
作者：
Jeon CY;Haan MN;Cheng C;Clayton ER;Mayeda ER;Miller JW;Aiello AE
慢性感染可能会导致慢性病的社会经济梯度。尽管慢性感染与炎性细胞因子水平升高和心血管疾病有关，但关于感染如何影响糖尿病风险的证据有限。我们在一个前瞻性的拉丁裔老年人队列中研究了慢性病毒和细菌感染的血清学证据与糖尿病发病之间的关系。我们分析了1998-1999年782名年龄>60岁且无糖尿病的患者的数据，这些患者的血液进行了单纯疱疹病毒1型、水痘病毒、巨细胞病毒、幽门螺杆菌和弓形虫抗体检测，并随访至2008年6月。我们采用考克斯比例风险回归法，通过调整年龄、性别、教育程度、心血管疾病、吸烟和胆固醇水平，估计糖尿病的相对发病率。单纯疱疹病毒1型、水痘病毒、巨细胞病毒和T.弓形虫感染者的糖尿病发病率并没有增加，而那些血清中H. pylori感染者在任何给定时间发生糖尿病的可能性是血清阴性个体的2.7倍（风险比2.69 [95%CI 1.10-6.60]）。控制胰岛素抵抗，C-反应蛋白和白细胞介素-6不能减弱H。幽门感染我们首次证明了H.在一项前瞻性队列研究中，幽门螺杆菌感染导致糖尿病发病率增加。我们的研究结果暗示了抗生素和胃肠道治疗在预防糖尿病中的潜在作用。
Chronic infections could be contributing to the socioeconomic gradient in chronic diseases. Although chronic infections have been associated with increased levels of inflammatory cytokines and cardiovascular disease, there is limited evidence on how infections affect risk of diabetes. We examined the association between serological evidence of chronic viral and bacterial infections and incident diabetes in a prospective cohort of Latino elderly. We analyzed data on 782 individuals aged >60 years and diabetes-free in 1998–1999, whose blood was tested for antibodies to herpes simplex virus 1, varicella virus, cytomegalovirus, Helicobacter pylori, and Toxoplasma gondii and who were followed until June 2008. We used Cox proportional hazards regression to estimate the relative incidence rate of diabetes by serostatus, with adjustment for age, sex, education, cardiovascular disease, smoking, and cholesterol levels. Individuals seropositive for herpes simplex virus 1, varicella virus, cytomegalovirus, and T. gondii did not show an increased rate of diabetes, whereas those who were seropositive for H. pylori at enrollment were 2.7 times more likely at any given time to develop diabetes than seronegative individuals (hazard ratio 2.69 [95% CI 1.10–6.60]). Controlling for insulin resistance, C-reactive protein and interleukin-6 did not attenuate the effect of H. pylori infection. We demonstrated for the first time that H. pylori infection leads to an increased rate of incident diabetes in a prospective cohort study. Our findings implicate a potential role for antibiotic and gastrointestinal treatment in preventing diabetes.
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影响因子：
7.6
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