lncRNAdb: a reference database for long noncoding RNAs.
lncRNAdb: a reference database for long noncoding RNAs.
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DOI：
10.1093/nar/gkq1138
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Mattick JS
中科院分区：
文献类型：
--
作者：
Amaral PP;Clark MB;Gascoigne DK;Dinger ME;Mattick JS
在真核生物中发现了大量具有很少或没有蛋白质编码潜力的长链rna[长链非编码rna (long noncoding RNAs, lncRNAs)]。与此同时，描述各种系统中单个lncrna的表达谱、分子特征和功能的数据也在不断积累。为了能够系统地汇编和更新这些信息，我们开发了一个数据库（lncRNAdb），其中包含了已被证明具有真核生物功能或与之相关的lncrna的全面列表，以及具有调节作用的信使rna。每个条目包含有关RNA的参考信息，包括序列、结构信息、基因组背景、表达、亚细胞定位、保存、功能证据和其他相关信息。lncRNAdb可以通过查询已发表的RNA名称和别名、序列、物种和相关的蛋白质编码基因，以及注释中包含的术语（如转录本表达的组织和相关疾病）来搜索。此外，lncRNAdb还与UCSC基因组浏览器和非编码RNA表达数据库（NRED）相连接，以获取各种来源的表达信息。lncRNAdb为有关lncrna及其与其他基因组元件的关联的文献提供了一个持续整理的平台。lncRNAdb可以访问：http://www.lncrnadb.org/。
Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs (lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the expression profiles, molecular features and functions of individual lncRNAs in a variety of systems are accumulating. To enable the systematic compilation and updating of this information, we have developed a database (lncRNAdb) containing a comprehensive list of lncRNAs that have been shown to have, or to be associated with, biological functions in eukaryotes, as well as messenger RNAs that have regulatory roles. Each entry contains referenced information about the RNA, including sequences, structural information, genomic context, expression, subcellular localization, conservation, functional evidence and other relevant information. lncRNAdb can be searched by querying published RNA names and aliases, sequences, species and associated protein-coding genes, as well as terms contained in the annotations, such as the tissues in which the transcripts are expressed and associated diseases. In addition, lncRNAdb is linked to the UCSC Genome Browser for visualization and Noncoding RNA Expression Database (NRED) for expression information from a variety of sources. lncRNAdb provides a platform for the ongoing collation of the literature pertaining to lncRNAs and their association with other genomic elements. lncRNAdb can be accessed at: http://www.lncrnadb.org/.
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