Comparative transcriptome analysis of Thitarodes armoricanus in response to the entomopathogenic fungi Paecilomyces hepiali and Ophiocordyceps sinensis
Comparative transcriptome analysis of Thitarodes armoricanus in response to the entomopathogenic fungi Paecilomyces hepiali and Ophiocordyceps sinensis
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盔甲硫蚴对昆虫病原真菌拟青霉和冬虫夏草反应的比较转录组分析
DOI：
10.3390/insects11010004
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发表时间：
2019-12
期刊：
影响因子：
3
通讯作者：
Han Richou
中科院分区：
文献类型：
--
作者：
Rao Zhongchen;Cao Li;Wu Hua;Qiu Xuehong;Liu Guiqing;Han Richou
Thitarodes armoricanus is a medicinal and economically important Lepidopteran insect species. The larvae infected by Paecilomyces hepiali survive no more than four days, while those infected by Ophiocordyceps sinensis can survive for several months before mummification. This provides a valuable comparative system to study interactions between an insect host and different pathogenic fungi. By using the T. armoricanus genome, a time-course transcriptome analysis of the whole larvae without guts was performed to explore the larvae response to P. hepiali and O. sinensis infection. A total of 3106 differentially expressed genes in five clusters were identified. The genes involved in coagulation and multiple metabolisms were both suppressed after P. hepiali or O. sinensis infection, whereas those related to environmental information responses, cell processes, biotic stimulus, and immunity (such as cecropin (CEC)) were elevated. The rapid death of T. armoricanus after P. hepiali infection might be caused by osmotic imbalance, immunocompromise (such as DEFs and GLVs), and nervous system dysfunction (glutamatergic synapse). Up-regulation of the genes related to cuticle structure, nervous system (such as neurotrophin signal pathway and dopaminergic synapse) and immune effectors (such as attacin (ATT) and proline-rich antimicrobial peptide 1 (PRAMP1)) in T. armoricanus, may contribute to the co-existence of T. armoricanus and O. sinensis. This study provides a global view and potential key genes of the interaction between T. armoricanus and two fungal entomopathogens.
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影响因子：
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