Asthma and farm exposures in a cohort of rural Iowa children.
Asthma and farm exposures in a cohort of rural Iowa children.
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哮喘和农场在爱荷华州农村的儿童队列中暴露。
DOI：
10.1289/ehp.7240
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发表时间：
2005-03
影响因子：
10.4
通讯作者：
Chrischilles EA
中科院分区：
文献类型：
--
作者：
Merchant JA;Naleway AL;Svendsen ER;Kelly KM;Burmeister LF;Stromquist AM;Taylor CD;Thorne PS;Reynolds SJ;Sanderson WT;Chrischilles EA
对农场儿童的流行病学研究引起了国际关注，因为农场儿童比非农场儿童更少发生过敏性反应，更少患过敏性疾病，更少患哮喘--研究结果与卫生假说一致。我们研究了一组爱荷华州农村儿童，以确定农场和其他环境危险因素与四种哮喘结局之间的关系：医生诊断的哮喘，医生诊断的哮喘/喘息药物，当前喘息和运动咳嗽。医生诊断的哮喘患病率为12%，但在超过三分之一的队列中至少发现了这四种健康结果之一。四种健康结果的多变量模型发现，（三种哮喘结局），年龄（三种哮喘结果），个人过敏史（四种哮喘结局）、过敏性疾病家族史（两个哮喘结局），早产（1例哮喘结局），早期呼吸道感染（三个哮喘结果），高风险出生（两个哮喘结果），以及农场暴露于养猪和饲料中添加抗生素（两个哮喘结果）。农村儿童哮喘和哮喘症状的高患病率强调了哮喘筛查计划和改善哮喘诊断和治疗的必要性。生活在养猪场的农场儿童哮喘健康结果的高患病率（44.1%，p = 0.01）和养猪加抗生素组（55.8%，p = 0.013），尽管特应性和个人过敏史的发生率较低，这表明需要提高认识和采取预防措施，研究的基础上，进一步评估环境和遗传因素的哮喘在农场儿童。
Epidemiologic studies of farm children are of international interest because farm children are less often atopic, have less allergic disease, and often have less asthma than do nonfarm children—findings consistent with the hygiene hypothesis. We studied a cohort of rural Iowa children to determine the association between farm and other environmental risk factors with four asthma outcomes: doctor-diagnosed asthma, doctor-diagnosed asthma/medication for wheeze, current wheeze, and cough with exercise. Doctor-diagnosed asthma prevalence was 12%, but at least one of these four health outcomes was found in more than a third of the cohort. Multivariable models of the four health outcomes found independent associations between male sex (three asthma outcomes), age (three asthma outcomes), a personal history of allergies (four asthma outcomes), family history of allergic disease (two asthma outcomes), premature birth (one asthma outcome), early respiratory infection (three asthma outcomes), high-risk birth (two asthma outcomes), and farm exposure to raising swine and adding antibiotics to feed (two asthma outcomes). The high prevalence of rural childhood asthma and asthma symptoms underscores the need for asthma screening programs and improved asthma diagnosis and treatment. The high prevalence of asthma health outcomes among farm children living on farms that raise swine (44.1%, p = 0.01) and raise swine and add antibiotics to feed (55.8%, p = 0.013), despite lower rates of atopy and personal histories of allergy, suggests the need for awareness and prevention measures and more population-based studies to further assess environmental and genetic determinants of asthma among farm children.
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影响因子：
2.4
作者：
Reynolds, S. J.;Donham, K. J.;Witten, P.
通讯作者：
Witten, P.
影响因子：
6.1
作者：
Downs, SH;Marks, GB;Peat, JK
通讯作者：
Peat, JK
影响因子：
14.2
作者：
Chrischilles, E;Ahrens, R;Merchant, J
通讯作者：
Merchant, J
DOI：
10.1164/ajrccm.152.3.7663792
发表时间：
1995-09-01
影响因子：
24.7
作者：
通讯作者：
--
影响因子：
10.4
作者：
Hamscher G;Pawelzick HT;Sczesny S;Nau H;Hartung J
通讯作者：
Hartung J