Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.
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DOI：
10.1146/annurev.nutr.012809.104755
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发表时间：
2010-08-21
影响因子：
8.9
通讯作者：
Aggarwal BB
中科院分区：
文献类型：
--
作者：
Aggarwal BB
过去二十年的广泛研究表明，肥胖是2型糖尿病、动脉粥样硬化、癌症和其他慢性疾病的主要危险因素，是一种促炎性疾病。几种香料已被证明通过抗氧化和抗炎机制表现出抗肥胖的活性。其中，姜黄素是一种来自香料姜黄（咖喱粉的重要成分）的黄色色素，已被广泛研究用于治疗肥胖和肥胖相关的代谢疾病。姜黄素直接与脂肪细胞、胰腺细胞、肝星状细胞、巨噬细胞和肌肉细胞相互作用。在那里，它抑制促炎性转录因子核因子-κ B、信号转导和转录激活因子-3和Wnt/β-连环蛋白，并激活过氧化物酶体增殖物激活受体-γ和Nrf 2细胞信号传导途径，从而导致脂肪因子下调，包括肿瘤坏死因子、白细胞介素-6、瘦素、单核细胞趋化蛋白-1，以及脂联素和其它基因产物的上调。这些姜黄素诱导的改变逆转胰岛素抵抗，高血糖症，高脂血症和其他与肥胖有关的症状。其他结构同源的营养品，如红辣椒、肉桂、丁香、黑胡椒和生姜，也表现出抗肥胖和胰岛素抵抗的作用。
Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/β-catenin, and it activates peroxisome proliferator-activated receptor-γ and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
7.9
作者：
Babu, P. Subash;Prabuseenivasan, S.;Ignacimuthu, S.
通讯作者：
Ignacimuthu, S.
影响因子：
6.1
作者：
Agbor, GA;Oben, JE;Vinson, JA
通讯作者：
Vinson, JA
影响因子：
3.7
作者：
Anand, Preetha;Kunnumakara, Ajaikumar B.;Sundaram, Chitra;Harikumar, Kuzhuvelil B.;Tharakan, Sheeja T.;Lai, Oiki S.;Sung, Bokyung;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
168.9
作者：
Bastard, JP;Caron, M;Capeau, J
通讯作者：
Capeau, J