Intestinal lymphoepithelial communication.
Intestinal lymphoepithelial communication.
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肠淋巴上皮通讯。
DOI：
--
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发表时间：
1999
影响因子：
--
通讯作者：
F. Shanahan
中科院分区：
文献类型：
--
作者：
F. Shanahan
肠道上皮细胞与淋巴细胞的紧密解剖并置促进了两种细胞类型之间的交流。这种细胞间对话对粘膜发育很重要，并对粘膜结构、功能和对组织损伤的反应有调节作用。淋巴上皮的通讯是双向的，在很大程度上是由共享的配体和受体介导的。涉及的化学信使包括细胞因子、生长因子、局部激素和花生四烯酸代谢产物。上皮与邻近淋巴样细胞之间的相互依赖性使得上皮被认为在粘膜免疫系统中具有中心作用，并且在粘膜免疫反应的传入和传出分支中都是一个积极的参与者。上皮细胞和邻近淋巴细胞之间的分子串扰只是肠粘膜内更复杂的细胞间信号网络的一个方面，粘膜的完整性依赖于这个网络。因此，神经细胞和免疫细胞之间、肠道菌群和上皮之间以及肠间充质细胞（包括成纤维细胞和血管内皮细胞）之间存在广泛的相互作用。粘膜微环境的任何方面的破坏，如选择性基因工程小鼠模型所实现的，都与粘膜防御和炎症受损有关。
The close anatomic juxtaposition of epithelial cells with lymphocytes lining the intestinal tract facilitates communication between the two cell types. This intercellular dialogue is important for mucosal development and has a conditioning effect on mucosal structure, function, and response to tissue injury. Lymphoepithelial communication is bi-directional, and mediated in large part, by shared ligands and receptors. The chemical messengers involved include cytokines, growth factors, local hormones, and products of arachidonate metabolism. The interdependency between the epithelium and adjacent lymphoid cells is such that the epithelium is considered to have a central role in the mucosal immune system and is an active participant in both the afferent and efferent limbs of the mucosal immune response. The molecular crosstalk between the epithelium and adjacent lymphocytes is just one aspect of a more complex network of intercellular signalling within the intestinal mucosa and upon which the integrity of the mucosa is dependent. Thus, there are extensive interactions between nerve and immune cells and between the enteric flora and the epithelium and amongst intestinal mesenchymal cells including fibroblasts and vascular endothelial cells. Disruption of any aspect of the mucosal microenvironment, as has been achieved with selective genetically engineered murine models, is associated with impaired mucosal defence and inflammation.
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影响因子：
15.9
作者：
MADARA, JL;STAFFORD, J
通讯作者：
STAFFORD, J
影响因子：
32.4
作者：
L. Puddington;S. Olson;L. Lefrançois
通讯作者：
L. Puddington;S. Olson;L. Lefrançois
影响因子：
15.9
作者：
Hershberg, RM;Framson, PE;Nepom, GT
通讯作者：
Nepom, GT
影响因子：
29.4
作者：
Singer, II;Kawka, DW;Stenson, WF
通讯作者：
Stenson, WF
影响因子：
15.9
作者：
MAYER, L;EISENHARDT, D
通讯作者：
EISENHARDT, D