An investigation of PreMCI: subtypes and longitudinal outcomes.
An investigation of PreMCI: subtypes and longitudinal outcomes.
复制标题
对PREMCI的调查：亚型和纵向结果。
DOI：
10.1016/j.jalz.2011.03.002
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Duara R
中科院分区：
文献类型：
--
作者：
Loewenstein DA;Greig MT;Schinka JA;Barker W;Shen Q;Potter E;Raj A;Brooks L;Varon D;Schoenberg M;Banko J;Potter H;Duara R
研究被认为不正常但不符合轻度认知功能障碍（MCI）标准的疾病的临床特征和进展率。我们纵向评估了269名老年受试者，他们在基线时不符合MCI的正式标准，但有：1）临床病史提示MCI无神经心理学缺陷（PreMCI-临床）;或2）一项或多项记忆测量的神经心理学缺陷结合阴性临床检查（遗忘PreMCI-NP）或神经心理学和临床检查均正常。NCI受试者在平均2 - 3年期间进展为MCI或痴呆的比率为3.7%，而所有PreMCI亚型的进展率显著更高（PreMCI-临床为22.0%，有两种或两种以上记忆障碍的遗忘型PreMCI-NP受试者为38.9%）。在整个PreMCI受试者中，物体记忆和类别流畅性测试的基线分数较低是进展为MCI或痴呆的最佳预测因子。心血管危险因素、帕金森症状和海马萎缩与疾病进展无关。根据临床和神经心理学评估定义的不同PreMCI亚型被发现具有不同的特征，但这两种亚型均表现出进展为MCI或痴呆的风险升高。尽管缺乏临床损害的证据，但在两个记忆领域中具有神经心理缺陷的受试者特别是其缺陷进展的风险增加。
To investigate the clinical features and rates of progression of conditions that are not considered to be normal, but do not fulfill criteria for mild cognitive impairment (MCI). We longitudinally evaluated 269 elderly subjects who did not meet formal criteria for MCI at baseline but had: 1) a clinical history suggesting MCI without neuropsychological deficits (PreMCI-Clinical); or 2) neuropsychological deficits on one or more memory measures in conjunction with a negative clinical examination (amnestic PreMCI-NP) or were normal on both neuropsychological and clinical examination. The rates of progression to MCI or dementia over an average 2 to 3 year period was 3.7% for NCI subjects, whereas it was significantly greater for all PreMCI subtypes (22.0% for PreMCI-Clinical, 38.9% for amnestic PreMCI-NP subjects with two or more memory impairments). Among PreMCI subjects as a whole, lower baseline scores on object memory and category fluency tests were the best predictors of progression to MCI or dementia. Cardiovascular risk factors, Parkinsonian symptoms and hippocampal atrophy were not associated with progression. Distinct PreMCI subtypes defined on the basis of clinical and neuropsychological evaluations were found to have distinct charateristics, but both subtypes demonstrated elevated risk for progression to MCI or dementia. Despite the lack of evidence of clinical impairment, subjects with neuropsychological deficits in two memory domains were particularly at increased risk for progression of their deficits.
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影响因子：
--
作者：
Dickerson, Bradford C.;Sperling, Reisa A.;Blacker, Deborah
通讯作者：
Blacker, Deborah
影响因子：
4.2
作者：
Chao, L. L.;Mueller, S. G.;Weiner, M. W.
通讯作者：
Weiner, M. W.
DOI：
10.1073/pnas.0900345106
发表时间：
2009-04-21
影响因子：
11.1
作者：
Reiman, Eric M.;Chen, Kewei;Caselli, Richard J.
通讯作者：
Caselli, Richard J.
影响因子：
9.9
作者：
Storandt, Martha;Grant, Elizabeth A.;Morris, John C.
通讯作者：
Morris, John C.
影响因子：
4
作者：
Duara, Ranjan;Loewenstein, David A.;Potter, Huntington
通讯作者：
Potter, Huntington