Association of the leptin-to-adiponectin ratio with metabolic syndrome in a sub-Saharan African population.
Association of the leptin-to-adiponectin ratio with metabolic syndrome in a sub-Saharan African population.
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撒哈拉以南非洲人群中瘦素/脂联素比率与代谢综合征的关系。
DOI：
10.1186/s13098-017-0265-6
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发表时间：
2017
影响因子：
4.8
通讯作者：
Sobngwi E
中科院分区：
文献类型：
--
作者：
Ayina CNA;Endomba FTA;Mandengue SH;Noubiap JJN;Ngoa LSE;Boudou P;Gautier JF;Mbanya JC;Sobngwi E
在世界范围内，主要由于生活方式的改变，代谢综合征的患病率增加，非洲人也没有摆脱这种情况。许多标志物已被研究，以预测这种综合征的风险，但最常用的是瘦素和脂联素。这些代谢标志物的数据在非洲是稀缺的，这项研究旨在评估瘦素与脂联素比值（LAR）与代谢综合征之间的关联在喀麦隆人口。这是一项横断面研究，包括喀麦隆一般人口中的476名成年人。收集的数据涉及体重指数、腰围、收缩压、舒张压、空腹血糖、血脂、脂联素、瘦素、胰岛素和用于评估胰岛素抵抗的稳态模型（HOMA-IR）。为了评估相关性，我们使用了斯皮尔曼分析，并使用二元逻辑回归分析进行了研究变量与代谢综合征的关联。瘦素/脂联素比值与体重指数呈显著正相关（r = 0.669，p < 0.0001），腰围（r = 0.595，p < 0.0001）、甘油三酯（r = 0.190，p = 0.001）、胰岛素水平（r = 0.333，p < 0.0001）和HOMA-IR（r = 0.306，p < 0.0001）。二元Logistic回归分析显示，瘦素、脂联素和LAR与代谢综合征显著相关，未校正OR分别为1.429、0.468和1.502。校正后，年龄和性别的相关性仍然显著; LAR还与代谢综合征（OR = 1.573，p值=0.000）以及较低水平的脂联素（OR = 0.359，p值=0.000）和较高水平的瘦素（OR = 1.469，p值=0.001）显著相关。这项研究表明，LAR与撒哈拉以南非洲人群的代谢综合征显著相关，与年龄和性别无关。
Worldwide there is an increased prevalence of metabolic syndrome mainly due to life-style modifications, and Africans are not saved of this situation. Many markers have been studied to predict the risk of this syndrome but the most used are leptin and adiponectin. Data on these metabolic markers are scare in Africa and this study aimed to assess the association between the leptin-to-adiponectin ratio (LAR) with metabolic syndrome in a Cameroonian population. This was a cross-sectional study that included 476 adults among a general population of Cameroon. Data collected concerned the body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, plasma lipids, adiponectin, leptin, insulin and homeostasis model for assessment of insulin resistance (HOMA-IR). To assess correlations we used Spearman’s analyses and association of the studied variables with metabolic syndrome were done using binary logistic regression analysis. The leptin to adiponectin ratio was significantly and positively correlated with the body mass index (r = 0.669, p < 0.0001), waist circumference (r = 0.595, p < 0.0001), triglycerides (r = 0.190, p = 0.001), insulin levels (r = 0.333, p < 0.0001) and HOMA-IR (r = 0.306, p < 0.0001). Binary logistic regression analysis revealed that leptin, adiponectin and LAR were significantly associated with metabolic syndrome with respective unadjusted OR of 1.429, 0.468 and 1.502. After adjustment, for age and sex, the associations remained significative; LAR was also found to be significantly associated with metabolic syndrome (OR = 1.573, p value =0.000) as well as lower levels of adiponectin (OR = 0.359, p value =0.000) and higher levels of leptin (OR = 1.469, p value =0.001). This study revealed that LAR is significantly associated with metabolic syndrome in sub-Saharan African population, independently to age and sex.
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影响因子：
4.3
作者：
Hughes, J. T.;O'Dea, K.;Maple-Brown, L. J.
通讯作者：
Maple-Brown, L. J.
影响因子：
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作者：
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Nour-Eldine W;Ghantous CM;Zibara K;Dib L;Issaa H;Itani HA;El-Zein N;Zeidan A
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作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
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作者：
Srikanthan K;Feyh A;Visweshwar H;Shapiro JI;Sodhi K
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