Biological Effects of Continuous Low-Dose-Rate Irradiation in Silkworms and Mice: Growth Promotion and Tumor Transplantability.
Biological Effects of Continuous Low-Dose-Rate Irradiation in Silkworms and Mice: Growth Promotion and Tumor Transplantability.
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DOI：
10.1177/1559325818811753
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Shibamoto Y
中科院分区：
文献类型：
--
作者：
Nakashima M;Sugie C;Wang Z;Kondo T;Manabe Y;Murai T;Shibamoto Y
此前的研究表明，持续低剂量率照射促进了蚕幼虫的生长。本研究旨在证实这一发现，确定促进生长的最佳剂量率，并比较低剂量率和高剂量率照射对蚕的影响，同时还研究辐射发射片对小鼠生长和肿瘤移植性的影响。将蚕卵放置在具有4种不同剂量率（γ射线率：1.7 -22.4 μSv/小时）的低剂量发射片或对照片上。其他组的蚕幼虫接受单次全身X射线照射（0.1-50 Gy），并监测随后的体重变化。从 3 周大开始，Balb/c 小鼠在同一张床单上饲养，并测量体重变化。七周后，小鼠被用来研究体外培养的EMT6肿瘤细胞的可移植性。在 13.4 和 22.4 μSv/小时片上繁殖的蚕变得比对照更大。单次50Gy照射抑制了蚕的生长。在低剂量率照射的小鼠中观察到 EMT6 肿瘤发展时间增加。这项研究证实了连续低剂量辐射可以促进蚕的生长，并证明高剂量率可以抑制生长。在小鼠中没有观察到生长促进作用；可能需要使用更高剂量率表进行进一步研究。
A previous study showed that continuous low-dose-rate irradiation promoted the growth of silkworm larvae. This study aimed to confirm that finding, determine the optimal dose rate for growth promotion, and compare low- and high-dose-rate irradiation in silkworms, while also investigating the effects of the radiation-emitting sheet on growth and tumor transplantability in mice. Silkworm eggs were placed on low-dose-emitting sheets with 4 different dose rates (γ-ray rate: 1.7 -22.4 μSv/hour) or on control sheets. The other groups of silkworm larvae received single whole-body X-irradiation (0.1-50 Gy), and subsequent body weight changes were monitored. Starting at 3 weeks old, Balb/c mice were bred on the same sheets, and body weight change was measured. Seven weeks later, the mice were used to investigate the transplantability of EMT6 tumor cells cultured in vitro. The silkworms bred on the 13.4- and 22.4-μSv/hour sheets became larger than the control. Single 50-Gy irradiation suppressed the growth of silkworms. An increase in the time to EMT6 tumor development was observed in low-dose-rate-irradiated mice. This study confirmed growth promotion of silkworms by continuous low-dose radiation and demonstrated growth suppression at a high dose rate. Growth promotion was not observed in mice; further studies using higher dose-rate sheets may be warranted.
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影响因子：
3.4
作者：
SHIBAMOTO, Y;STREFFER, C;BUDACH, V
通讯作者：
BUDACH, V
影响因子：
3.4
作者：
Ishii, K;Hosoi, Y;Sakamoto, K
通讯作者：
Sakamoto, K
影响因子：
2.5
作者：
Shibamoto, Yuta;Kamei, Yoshiaki;Aoyama, Natsuto
通讯作者：
Aoyama, Natsuto
DOI：
10.1177/1559325817735478
发表时间：
2017-10
期刊：
Dose-response : a publication of International Hormesis Society
影响因子：
--
作者：
Calabrese EJ
通讯作者：
Calabrese EJ
DOI：
10.1177/1559325817717839
发表时间：
2017-07
期刊：
Dose-response : a publication of International Hormesis Society
影响因子：
--
作者：
Sacks B;Siegel JA
通讯作者：
Siegel JA