The Mistaken Birth and Adoption of LNT: An Abridged Version.
The Mistaken Birth and Adoption of LNT: An Abridged Version.
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DOI：
10.1177/1559325817735478
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Calabrese EJ
中科院分区：
文献类型：
--
作者：
Calabrese EJ
癌症风险评估的历史基础是基于Hermann J. Muller发现x射线诱导的基因突变，将其转化为线性非阈值（LNT）单次攻击理论，该模型由美国国家科学院，原子辐射生物效应I，遗传学小组于1956年推荐，随后被全球监管机构广泛采用。这篇文章总结了这段历史最近的大量历史启示，这些启示深刻地挑战了标准和广泛接受的癌症风险评估历史，显示了多个重大的科学错误和不正确的解释，夹杂着主要意识形态动机的辐射遗传学家对科学记录的故意歪曲。这些新颖的历史发现表明，LNT单一命中模型的科学基础存在严重缺陷，不应被用于癌症风险评估。
The historical foundations of cancer risk assessment were based on the discovery of X-ray-induced gene mutations by Hermann J. Muller, its transformation into the linear nonthreshold (LNT) single-hit theory, the recommendation of the model by the US National Academy of Sciences, Biological Effects of Atomic Radiation I, Genetics Panel in 1956, and subsequent widespread adoption by regulatory agencies worldwide. This article summarizes substantial recent historical revelations of this history, which profoundly challenge the standard and widely acceptable history of cancer risk assessment, showing multiple significant scientific errors and incorrect interpretations, mixed with deliberate misrepresentation of the scientific record by leading ideologically motivated radiation geneticists. These novel historical findings demonstrate that the scientific foundations of the LNT single-hit model were seriously flawed and should not have been adopted for cancer risk assessment.
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影响因子：
1.5
作者：
Selby, PB
通讯作者：
Selby, PB
影响因子：
8.3
作者：
Calabrese, Edward J.
通讯作者：
Calabrese, Edward J.
影响因子：
10.3
作者：
ALBERT, RE;TRAIN, RE;ANDERSON, E
通讯作者：
ANDERSON, E
影响因子：
1.5
作者：
Selby, PB
通讯作者：
Selby, PB
影响因子：
8.3
作者：
Calabrese, Edward J.
通讯作者：
Calabrese, Edward J.