Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment.
Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment.
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DOI：
10.1002/dvdy.21613
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发表时间：
2008-10
影响因子：
2.5
通讯作者：
Kulesa, Paul M.
中科院分区：
文献类型：
--
作者：
Kasemeier-Kulesa, Jennifer C.;Teddy, Jessica M.;Postovit, Lynne-Marie;Seftor, Elisabeth A.;Seftor, Richard E. B.;Hendrix, Mary J. C.;Kulesa, Paul M.
胚胎微环境是对多能细胞进行编程以采用特定命运和迁移路径的重要信号源，但其重新编程和限制多能肿瘤细胞命运和侵袭的潜力尚未实现。侵袭性肿瘤细胞与多能、侵袭性胚胎祖细胞具有许多共同特征，有助于肿瘤细胞可塑性的范例。在脊椎动物胚胎中，多种细胞类型源自称为神经嵴的高度侵袭性细胞群。神经嵴和它们迁移通过的胚胎微环境代表了研究胚胎发生和表型确定过程中细胞多样化的优秀模型系统。最近对移植到各种胚胎模型（包括富含神经嵴的雏鸡微环境）中的肿瘤细胞进行的令人兴奋的研究揭示了控制和恢复转移表型的潜力，表明进一步的工作可能有助于确定源自致瘤和胚胎信号融合的治疗干预的新靶标。在这篇小综述中，我们总结了神经嵴和高度侵袭性人类黑色素瘤细胞常见的标记。我们强调了我们对在鸡神经嵴丰富的微环境中研究的肿瘤细胞行为和可塑性的理解的进展。在此，我们向 Elizabeth D. Hay 教授对发育生物学和癌症生物学这一重要领域做出的巨大贡献表示敬意。
The embryonic microenvironment is an important source of signals that program multipotent cells to adopt a particular fate and migratory path, yet its potential to reprogram and restrict multipotent tumor cell fate and invasion is unrealized. Aggressive tumor cells share many characteristics with multipotent, invasive embryonic progenitors, contributing to the paradigm of tumour cell plasticity. In the vertebrate embryo, multiple cell types originate from a highly invasive cell population called the neural crest. The neural crest and the embryonic microenvironments they migrate through represent an excellent model system to study cell diversification during embryogenesis and phenotype determination. Recent exciting studies of tumor cells transplanted into various embryo models, including the neural crest rich chick microenvironment, have revealed the potential to control and revert the metastatic phenotype, suggesting further work may help to identify new targets for therapeutic intervention derived from a convergence of tumorigenic and embryonic signals. In this mini-review, we summarize markers that are common to the neural crest and highly aggressive human melanoma cells. We highlight advances in our understanding of tumor cell behaviors and plasticity studied within the chick neural crest rich microenvironment. In so doing, we honor the tremendous contributions of Professor Elizabeth D. Hay towards this important interface of developmental and cancer biology.
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