White Matter Correlates of Mild Traumatic Brain Injuries in Women Subjected to Intimate-Partner Violence: A Preliminary Study.
White Matter Correlates of Mild Traumatic Brain Injuries in Women Subjected to Intimate-Partner Violence: A Preliminary Study.
复制标题
白质与遭受亲密伴侣暴力的女性轻度创伤性脑损伤的相关性：一项初步研究。
DOI：
10.1089/neu.2018.5734
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发表时间：
2019
影响因子：
4.2
通讯作者：
Adra,Noor
中科院分区：
文献类型：
--
作者：
Valera,EveM;Cao,Aihua;Pasternak,Ofer;Shenton,MarthaE;Kubicki,Marek;Makris,Nikos;Adra,Noor
大部分（44-75%）经历过亲密伴侣暴力的妇女被证明遭受虐待者的重复性轻度创伤性脑损伤。此外，尽管要求对TBI相关的健康结果进行研究，但目前只有少数研究解决了这个问题，并且只有一项先前的成像研究调查了IPV相关TBI的神经相关性。作为回应，我们检查了20名有IPV病史的女性的白色物质微结构的特定区域。受试者在3特斯拉Siemens Magnetom TrioTim扫描仪上使用扩散磁共振成像进行成像。我们研究了反映IPV相关mTBI的数量和近度的评分与后辐射冠和上级辐射冠以及后丘脑辐射的各向异性分数（FA）之间的相关性，这些脑区先前被证明参与mTBI。我们还调查了几个认知措施，即学习，记忆和认知灵活性，和FA在白色物质感兴趣的地区之间的关联。我们报告了放射冠后部和上级区域的脑损伤评分和FA之间的负相关性。我们未能找到我们的认知措施和FA在这些地区之间的关联，但这些结果的解释仍然是不确定的，由于可能的权力问题。总的来说，这些数据建立在小但不断增长的文献基础上，证明了mTBI对经历IPV的女性的潜在后果，并进一步强调了在这一领域进行更大规模和更全面研究的迫切需要。
A large proportion (range of 44–75%) of women who experience intimate-partner violence (IPV) have been shown to sustain repetitive mild traumatic brain injuries (mTBIs) from their abusers. Further, despite requests for research on TBI-related health outcomes, there are currently only a handful of studies addressing this issue and only one prior imaging study that has investigated the neural correlates of IPV-related TBIs. In response, we examined specific regions of white matter microstructure in 20 women with histories of IPV. Subjects were imaged on a 3-Tesla Siemens Magnetom TrioTim scanner using diffusion magnetic resonance imaging. We investigated the association between a score reflecting number and recency of IPV-related mTBIs and fractional anisotropy (FA) in the posterior and superior corona radiata as well as the posterior thalamic radiation, brain regions shown previously to be involved in mTBI. We also investigated the association between several cognitive measures, namely learning, memory, and cognitive flexibility, and FA in the white matter regions of interest. We report a negative correlation between the brain injury score and FA in regions of the posterior and superior corona radiata. We failed to find an association between our cognitive measures and FA in these regions, but the interpretation of these results remains inconclusive due to possible power issues. Overall, these data build upon the small but growing literature demonstrating potential consequences of mTBIs for women experiencing IPV, and further underscore the urgent need for larger and more comprehensive studies in this area.
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