Social ecological factors and medication treatment for opioid use disorder among justice-involved rural and urban persons: the Geographic variation in Addiction Treatment Experiences (GATE) longitudinal cohort study protocol.

Social ecological factors and medication treatment for opioid use disorder among justice-involved rural and urban persons: the Geographic variation in Addiction Treatment Experiences (GATE) longitudinal cohort study protocol.
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DOI:
10.1136/bmjopen-2022-066068
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发表时间:
2023-03-20
期刊:
影响因子:
2.9
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
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三种药物是食品和药物管理局批准用于治疗阿片类药物使用障碍(OUD)的药物;然而,这些药物在监狱中使用不足,这增加了阿片类药物使用障碍(POUD)患者被释放时复发和过量的风险。关于POUD愿意在监狱中开始阿片类药物使用障碍(MOUD)的药物治疗以及他们在释放后继续参与治疗的多层次因素的研究很少。此外,没有对农村和城市人口进行比较。成瘾治疗经验的地理差异(GATE)研究旨在确定影响监狱缓释注射纳洛酮(XR-NTX)和丁丙诺啡启动的多层次因素(即个人,个人网络和结构因素),并将检查农村和城市POUD中释放后MOUD使用和不良结局(即复发,过量,累犯)的预测因素。这种混合方法的研究采用了社会生态框架。正在对450名POUD进行一项前瞻性观察性纵向队列研究,使用在监狱、释放后立即、释放后6个月和释放后12个月收集的调查和社交网络数据,以确定关键结果的多层次城乡差异。正在与POUD、监狱治疗人员和社会服务临床医生进行深入的定性访谈。为了最大限度地提高严谨性和可重复性,我们采用了并行三角测量策略,定性和定量数据对分析的贡献相等,并在检查科学目标时用于交叉验证。GATE研究在实施前由肯塔基州大学的机构审查委员会审查和批准。调查结果将通过在科学和专业协会会议上的演讲、同行评议的期刊出版物和提交给肯塔基州惩教部的汇总报告进行传播。
Three medications are Food and Drug Administration approved for the treatment of opioid use disorder (OUD); however, these medications are underused within prisons, which elevates the risk of relapse and overdose when persons with opioid use disorder (POUD) are released. Research is scant regarding the multilevel factors associated with POUDs’ willingness to initiate medication treatment for opioid use disorder (MOUD) while in prison and their continued engagement in treatment after release. Furthermore, rural and urban populations have not been compared. The Geographic variation in Addiction Treatment Experiences (GATE) study seeks to identify multilevel factors (ie, individual, personal network, and structural factors) influencing prison-based extended-release injectable naltrexone (XR-NTX) and buprenorphine initiation and will examine predictors of postrelease MOUD use and adverse outcomes (ie, relapse, overdose, recidivism) among both rural and urban POUDs. This mixed methods study employs a social ecological framework. A prospective observational longitudinal cohort study is being conducted with 450 POUDs using survey and social network data collected in prison, immediately postrelease, 6 months postrelease and 12 months postrelease to identify multilevel rural-urban variation in key outcomes. In-depth qualitative interviews are being conducted with POUDs, prison-based treatment staff and social service clinicians. To maximise rigour and reproducibility, we employ a concurrent triangulation strategy, whereby qualitative and quantitative data contribute equally to the analysis and are used for cross-validation when examining scientific aims. The GATE study was reviewed and approved by the University of Kentucky’s Institutional Review Board prior to implementation. Findings will be disseminated through presentations at scientific and professional association conferences, peer-reviewed journal publications and a summary aggregate report submitted to the Kentucky Department of Corrections.
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