Expression profiling of constitutive mast cells reveals a unique identity within the immune system.
Expression profiling of constitutive mast cells reveals a unique identity within the immune system.
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肥大细胞是进化上古老的哨兵细胞。与嗜碱性粒细胞一样，肥大细胞表达高亲和力IgE受体，并参与宿主防御和多种免疫介导的疾病。为了更好地表征这些细胞的功能，我们评估了从外周结缔组织分离的肥大细胞和从脾脏和血液分离的嗜碱性粒细胞的转录谱。我们发现肥大细胞在转录上是不同的，独立于所有其他异形细胞聚集，并且肥大细胞在组织中表现出比以前认识到的更大的异质性。我们观察到肥大细胞和嗜碱性粒细胞之间的同源性极小，它们与其他循环粒细胞的重叠比与肥大细胞的重叠更多。肥大细胞和嗜碱性粒细胞转录特征的衍生强调了它们检测环境信号和影响炎症环境的不同能力。
Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity IgE receptor and are implicated in host defense and diverse immune-mediated diseases. To better characterize the function of these cells, we assessed the transcriptional profiles of mast cells isolated from peripheral connective tissues and basophils isolated from spleen and blood. We found that mast cells were transcriptionally distinct, clustering independently from all other profiled cells, and that mast cells demonstrated considerably greater heterogeneity across tissues than previously appreciated. We observed minimal homology between mast cells and basophils, which share more overlap with other circulating granulocytes than with mast cells. Derivation of mast cell and basophil transcriptional signatures underscores their differential capacity to detect environmental signals and influence the inflammatory milieu.
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DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Ericson, Jeffrey A.;Duffau, Pierre;Monach, Paul A.
通讯作者：
Monach, Paul A.
DOI：
10.4049/jimmunol.0901471
发表时间：
2009-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jones TG;Hallgren J;Humbles A;Burwell T;Finkelman FD;Alcaide P;Austen KF;Gurish MF
通讯作者：
Gurish MF
鉴定小鼠和男性的抗性和循环皮肤树突状细胞种群。
影响因子：
15.3
作者：
Bogunovic, Milena;Ginhoux, Florent;Wagers, Amy;Loubeau, Martine;Isola, Luis M.;Lubrano, Lauren;Najfeld, Vesna;Phelps, Robert G.;Grosskreutz, Celia;Scigliano, Eilleen;Frenette, Paul S.;Merad, Miriam
通讯作者：
Merad, Miriam
影响因子：
4.8
作者：
Cavalcante, MCM;Allodi, S;Pavao, MSG
通讯作者：
Pavao, MSG